Model organism
Killifish
- Works
- 6
- Most cited
- 238
Most-cited works
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain aging in the short-lived vertebrate Nothobra...
Integrating telomere biology into the ecology and evolution of natural populations: Progress and prospects
Telomeres are fascinating stretches of protective DNA that cap the chromosome ends of eukaryotes. Without telomeres, during cell division and DNA replication, DNA repair proteins would misread the ends of chromosomes and attempt to repair o...
Sex as a biological variable in ageing: insights and perspectives on the molecular and cellular hallmarks
Sex-specific differences in lifespan and ageing are observed in various species. In humans, women generally live longer but are frailer and suffer from different age-related diseases compared to men. The hallmarks of ageing, such as genomic...
Enhanced C/EBPα Function Extends Healthspan and Lifespan in the African Turquoise Killifish.
The transcription factor CCAAT/enhancer binding protein alpha (C/EBPα) regulates cell differentiation, proliferation, and function in various tissues, including the liver, adipose tissue, skin, lung, and hematopoietic system. Studies in rat...
Germ cells are hidden contributors of sex differences in vertebrate lifespan.
Aging is a complex biological process whose regulatory mechanisms remain incompletely understood. Accumulating evidence indicates that germ cells play pivotal roles in the systemic regulation of aging. The link between germ cells and somati...
A short-lived fish with long-lasting effects: hallmarks of aging in <i>Nothobranchius furzeri</i>.
Our world is facing a global aging crisis with an increasing number of people living longer in poor health, as indicated by a gap between lifespan and healthspan. It is necessary to improve our knowledge of the biomolecular and cellular pat...