Model organism
Killifish
- Works
- 443
- Most cited
- 434
Most-cited works
Regulation of life span by the gut microbiota in the short-lived African turquoise killifish
Gut bacteria occupy the interface between the organism and the external environment, contributing to homeostasis and disease. Yet, the causal role of the gut microbiota during host aging is largely unexplored. Here, using the African turquo...
Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses
Aging is accompanied by the functional decline of tissues. However, a systematic study of epigenomic and transcriptomic changes across tissues during aging is missing. Here, we generated chromatin maps and transcriptomes from four tissues a...
From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology
African annual fishes from the genus Nothobranchius are small teleosts that inhabit temporary water bodies subject to annual desiccation due to the alternation of the monsoon seasons. Given their unique biology, these fish have emerged as a...
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain aging in the short-lived vertebrate Nothobra...
Temperature affects longevity and age‐related locomotor and cognitive decay in the short‐lived fish Nothobranchius furzeri
Temperature variations are known to modulate aging and life-history traits in poikilotherms as different as worms, flies and fish. In invertebrates, temperature affects lifespan by modulating the slope of age-dependent acceleration in death...
A molecular phylogeny for aplocheiloid fishes (Atherinomorpha, Cyprinodontiformes): the role of vicariance and the origins of annualism
Annual aplocheiloid killifish embryos possess a rare ability among vertebrates to enter stages of developmental arrest (diapause) when subjected to adverse environmental conditions. Previous morphological analyses have presented disparate h...
Large Differences in Aging Phenotype between Strains of the Short-Lived Annual Fish Nothobranchius furzeri
BACKGROUND: A laboratory inbred strain of the annual fish Nothobranchius furzeri shows exceptionally short life expectancy and accelerated expression of age markers. In this study, we analyze new wild-derived lines of this short-lived speci...
The African turquoise killifish: A research organism to study vertebrate aging and diapause
The African turquoise killifish has recently gained significant traction as a new research organism in the aging field. Our understanding of aging has strongly benefited from canonical research organisms-yeast, C. elegans, Drosophila, zebra...
Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan
Mutations and genetic variability affect gene expression and lifespan, but the impact of variations in gene expression within individuals on their aging-related mortality is poorly understood. We performed a longitudinal study in the short-...
Rapid growth, early maturation and short generation time in African annual fishes
BACKGROUND: Extreme environmental conditions can give rise to extreme adaptations. We document growth, sexual maturation and fecundity in two species of African annual fish inhabiting temporary savanna pools. RESULTS: Nothobranchius kadleci...
Nerve growth factor and Trk high affinity receptor (TrkA) gene expression in inflammatory bowel disease
Abstract Repetitive DNA represents an important driver of sex chromosome differentiation. Yet, repetitive sequences tend to be misrepresented or overlooked in genomic studies. We analysed repetitive DNA landscape of sex chromosomes in sever...
Laboratory breeding of the short-lived annual killifish Nothobranchius furzeri
This 2016 Nature Protocols article details methods for the laboratory breeding and maintenance of the short-lived annual killifish Nothobranchius furzeri.