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When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response

Matías González-Quiroz, Alice Blondel, Alfredo Sagredo, Claudio Hetz, Éric Chevet, Rémy Pedeux

Trends in Cell Biology · 2020 · ▲ 103 citations

Genomic instability Epigenetic alterations Loss of proteostasis Mitochondrial dysfunction Cellular senescence Altered intercellular communication Chronic inflammation Human

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Abstract

Sustaining both proteome and genome integrity (GI) requires the integration of a wide range of mechanisms and signaling pathways. These comprise, in particular, the unfolded protein response (UPR) and the DNA damage response (DDR). These adaptive mechanisms take place respectively in the endoplasmic reticulum (ER) and in the nucleus. UPR and DDR alterations are associated with aging and with pathologies such as degenerative diseases, metabolic and inflammatory disorders, and cancer. We discuss the emerging signaling crosstalk between UPR stress sensors and the DDR, as well as their involvement in cancer biology.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.tcb.2020.09.002
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Fetched: 2026-06-14 MST

Cite this

APA

González-Quiroz, M., Blondel, A., Sagredo, A., Hetz, C., Chevet, �., & Pedeux, R. (2020). When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response. <em>Trends in Cell Biology</em>. https://doi.org/10.1016/j.tcb.2020.09.002

Vancouver

González-Quiroz M, Blondel A, Sagredo A, Hetz C, Chevet �, Pedeux R. When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response. Trends in Cell Biology. 2020. doi:10.1016/j.tcb.2020.09.002.

BibTeX

@article{matas2020WhenEn, title = {When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response}, author = {Matías González-Quiroz and Alice Blondel and Alfredo Sagredo and Claudio Hetz and Éric Chevet and Rémy Pedeux}, journal = {Trends in Cell Biology}, year = {2020}, doi = {10.1016/j.tcb.2020.09.002}, }