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Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

Anurag Singh, Davide D’Amico, Pénélope A. Andreux, Andréane M. Fouassier, William Blanco-Bose, Malkanthi Evans, Patrick Aebischer, Johan Auwerx, Chris Rinsch

Cell Reports Medicine · 2022 · ▲ 216 citations

Disabled macroautophagy Mitochondrial dysfunction Chronic inflammation Exercise

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Abstract

]) and physical performance (6 min walk test) but do not notice a significant improvement on peak power output (primary endpoint). Levels of plasma acylcarnitines and C-reactive proteins are significantly lower with Urolithin A, indicating higher mitochondrial efficiency and reduced inflammation. We also examine expression of proteins linked to mitophagy and mitochondrial metabolism in skeletal muscle and find a significant increase with Urolithin A administration. This study highlights the benefit of Urolithin A to improve muscle performance.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.xcrm.2022.100633
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Fetched: 2026-06-24 MST

Cite this

APA

Singh, A., D’Amico, D., Andreux, P.A., Fouassier, A.M., Blanco-Bose, W., Evans, M., Aebischer, P., Auwerx, J., & Rinsch, C. (2022). Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. <em>Cell Reports Medicine</em>. https://doi.org/10.1016/j.xcrm.2022.100633

Vancouver

Singh A, D’Amico D, Andreux PA, Fouassier AM, Blanco-Bose W, Evans M, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine. 2022. doi:10.1016/j.xcrm.2022.100633.

BibTeX

@article{anurag2022Urolit, title = {Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults}, author = {Anurag Singh and Davide D’Amico and Pénélope A. Andreux and Andréane M. Fouassier and William Blanco-Bose and Malkanthi Evans and Patrick Aebischer and Johan Auwerx and Chris Rinsch}, journal = {Cell Reports Medicine}, year = {2022}, doi = {10.1016/j.xcrm.2022.100633}, }