Citation only via OpenAlex

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Shin‐ichiro Imai, Christopher M. Armstrong, Matt Kaeberlein, Leonard Guarente

Nature · 2000 · ▲ 3,475 citations

Epigenetic alterations

Abstract

A 2000 Nature study demonstrates that the yeast Sir2 transcriptional silencing and longevity protein functions as an NAD-dependent histone deacetylase.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.1038/35001622
Canonical: link ↗
Fetched: 2026-05-31 MST

Cite this

APA

Imai, S., Armstrong, C.M., Kaeberlein, M., & Guarente, L. (2000). Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. <em>Nature</em>. https://doi.org/10.1038/35001622

Vancouver

Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 2000. doi:10.1038/35001622.

BibTeX

@article{shinichiro2000Transc, title = {Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase}, author = {Shin‐ichiro Imai and Christopher M. Armstrong and Matt Kaeberlein and Leonard Guarente}, journal = {Nature}, year = {2000}, doi = {10.1038/35001622}, }