Author
Leonard Guarente
- Indexed works
- 35
- Total citations
- 20,495
- Active years
- 19
Collaborators
Works in the record
Nature 2000
Citation only
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Genes & Development 1999
Open access · OA
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
Nature 2001
Citation only
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Genes & Development 2006
Preprint
Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
Cell 2013
Open access · OA
The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
Trends in Endocrinology and Metabolism 2014
Open access · OA
SIRT1 and other sirtuins in metabolism
Nature Reviews Molecular Cell Biology 2005
Citation only
Calorie restriction, SIRT1 and metabolism: understanding longevity
Genes & Development 2000
Preprint · OA
Sir2 links chromatin silencing, metabolism, and aging
Aging Cell 2007
Open access · OA
SIRT1 transgenic mice show phenotypes resembling calorie restriction
Cell 2013
Open access · OA
SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging
Genes & Development 2008
Preprint · OA
Tissue-specific regulation of SIRT1 by calorie restriction
Cell 2008
Preprint · OA
Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
Genes & Development 2013
Preprint · CC-BY
Calorie restriction and sirtuins revisited
Nature Genetics 2004
Citation only
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
Genes & Development 2003
Preprint · OA
How does calorie restriction work?
npj Aging and Mechanisms of Disease 2016
Open access · CC-BY
It takes two to tango: NAD+ and sirtuins in aging/longevity control
Trends in Pharmacological Sciences 2010
Open access · OA
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases
Cold Spring Harbor Symposia on Quantitative Biology 2007
Preprint · OA
Sirtuins in Aging and Disease
EMBO Molecular Medicine 2013
Open access · CC-BY
SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin
Molecular Cell 2011
Open access · OA
The SirT3 Divining Rod Points to Oxidative Stress
The Annual Review of Pharmacology and Toxicology 2011
Open access · OA
Small-Molecule Allosteric Activators of Sirtuins
Cell Research 2013
Open access · CC-BY
Sirtuin deacetylases in neurodegenerative diseases of aging
Cell Reports 2013
Open access · CC-BY
SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis
Cold Spring Harbor Symposia on Quantitative Biology 2011
Preprint · OA
Sirtuins, Aging, and Metabolism
Genes & Development 2009
Preprint · OA
Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
npj Aging and Mechanisms of Disease 2017
Open access · CC-BY
Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study
Proceedings of the National Academy of Sciences 1999
Open access · OA
Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae
Aging Cell 2019
Open access · CC-BY
NAD + supplementation rejuvenates aged gut adult stem cells
PLoS ONE 2017
Open access · CC-BY
SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis
Nature Communications 2016
Open access · CC-BY
Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway
Annual Review of Physiology 2012
Preprint · OA
Metabolic and Neuropsychiatric Effects of Calorie Restriction and Sirtuins
Cell 2014
Open access · OA
Aging Research—Where Do We Stand and Where Are We Going?
BMC Nephrology 2020
Open access · CC-BY
Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI
The FASEB Journal 2010
Citation only
SIRTUINS, AGING AND DISEASE
BMC Proceedings 2012
Open access · CC-BY