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Taurine deficiency as a driver of aging

Pradeep Kumar Singh, Kishore Gollapalli, Stefano Mangiola, Daniela Schranner, Yusuf MA, Manish Chamoli, Shi SL, Lopes Bastos B, T. Murlidharan Nair, Annett Riermeier, Vayndorf EM, Wu JZ, Aishwarya Shrikant Nilakhe, Nguyen CQ, Michael Muir

Yearbook of pediatric endocrinology · 2023 · ▲ 3 citations

Genomic instability Telomere attrition Epigenetic alterations Mitochondrial dysfunction Chronic inflammation Human Mouse

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Abstract

In Brief: The authors describe a wide range of studies. Firstly, observational studies showed that circulating taurine concentrations decline with age in mice, monkeys, and humans and in the latter, low taurine was associated with metabolic disease (abdominal fat, blood pressure, Type 2 diabetes). They then gave oral taurine to mice throughout their lives and showed that this increased lifespan by 1012% and improved functional outcomes of almost all tissues studied (bone, muscle, pancreas, brain, fat, gut, and immune system). Similarly, they found that taurine supplementation improved almost all known cellular mechanisms of ageing, including: DNA damage repair, telomere protection, epigenetic markers of ageing, mitochondrial function and inflammation.

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Provenance

Source: OpenAlex
DOI: 10.1530/ey.20.13.1
Canonical: link ↗
Fetched: 2026-06-23 MST

Cite this

APA

Singh, P.K., Gollapalli, K., Mangiola, S., Schranner, D., MA, Y., Chamoli, M., SL, S., B, L.B., Nair, T.M., Riermeier, A., EM, V., JZ, W., Nilakhe, A.S., CQ, N., Muir, M., MG, K., Foulger, A., Junker, A., Devine, J., & Sharan, K. (2023). Taurine deficiency as a driver of aging. <em>Yearbook of pediatric endocrinology</em>. https://doi.org/10.1530/ey.20.13.1

Vancouver

Singh PK, Gollapalli K, Mangiola S, Schranner D, MA Y, Chamoli M, et al. Taurine deficiency as a driver of aging. Yearbook of pediatric endocrinology. 2023. doi:10.1530/ey.20.13.1.

BibTeX

@article{pradeep2023Taurin, title = {Taurine deficiency as a driver of aging}, author = {Pradeep Kumar Singh and Kishore Gollapalli and Stefano Mangiola and Daniela Schranner and Yusuf MA and Manish Chamoli and Shi SL and Lopes Bastos B and T. Murlidharan Nair and Annett Riermeier and Vayndorf EM and Wu JZ and Aishwarya Shrikant Nilakhe and Nguyen CQ and Michael Muir and Kiflezghi MG and Anna Foulger and Alex Junker and Jenifer Devine and Kishori Sharan and Chinta SJ and Satyendra Kumar Rajput and Ajay Rane and Philipp Baumert and Martin Schönfelder}, journal = {Yearbook of pediatric endocrinology}, year = {2023}, doi = {10.1530/ey.20.13.1}, }