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Sub-lethal apoptotic stress enables mtDNA release during senescence and drives the SASP

João F. Passos, James Chapman, Hanna Salmonowicz, Stella G. Victorelli, Hélène Martini, Joel S. Riley, Catherine Cloix, Gerald S. Shadel, Jair Machado Espíndola‐Netto, Diana Jurk, Anthony B. Lagnado, Lilian Sales Gomez, Joshua N. Farr, Dominik Saul, Becca Reed

Research Square · 2022 · ▲ 3 citations

Abstract

This 2022 Research Square study examines the role of sub-lethal apoptotic stress in mitochondrial DNA release during cellular senescence(definition) and the SASP.

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Provenance

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OpenAlex
DOI
10.21203/rs.3.rs-1247316/v1
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Fetched
2026-10-05 MST

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APA
Passos, J.F., Chapman, J., Salmonowicz, H., Victorelli, S.G., Martini, H., Riley, J.S., Cloix, C., Shadel, G.S., Espíndola‐Netto, J.M., Jurk, D., Lagnado, A.B., Gomez, L.S., Farr, J.N., Saul, D., Reed, B., Greaves, L.C., Mann, D.A., Masuda, C.A., Khosla, S., &amp; Dai, H. (2022). Sub-lethal apoptotic stress enables mtDNA release during senescence and drives the SASP. <em>Research Square</em>. https://doi.org/10.21203/rs.3.rs-1247316/v1
Vancouver
Passos JF, Chapman J, Salmonowicz H, Victorelli SG, Martini H, Riley JS, et al. Sub-lethal apoptotic stress enables mtDNA release during senescence and drives the SASP. Research Square. 2022. doi:10.21203/rs.3.rs-1247316/v1.
BibTeX
@unpublished{joo2022Sublet, title = {Sub-lethal apoptotic stress enables mtDNA release during senescence and drives the SASP}, author = {João F. Passos and James Chapman and Hanna Salmonowicz and Stella G. Victorelli and Hélène Martini and Joel S. Riley and Catherine Cloix and Gerald S. Shadel and Jair Machado Espíndola‐Netto and Diana Jurk and Anthony B. Lagnado and Lilian Sales Gomez and Joshua N. Farr and Dominik Saul and Becca Reed and Laura C. Greaves and Derek A. Mann and Cláudio A. Masuda and Sundeep Khosla and Haiming Dai and Nathan K. LeBrasseur and Viktor I. Korolchuk and Xue Shae and Peter D. Adams and Stephen W. G. Tait}, journal = {Research Square}, year = {2022}, doi = {10.21203/rs.3.rs-1247316/v1}, }

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