Skip to content
AgingNexus
☰ Menu
Open access · OA via OpenAlex

<i>N</i> -acyl taurines are endogenous lipid messengers that improve glucose homeostasis

Trisha J. Grevengoed, Samuel A.J. Trammell, Michele K. McKinney, Natalia Petersen, Rebecca Cardone, Jens S. Svenningsen, Daisuke Ogasawara, Christina Nexøe-Larsen, Filip K. Knop, Thue W. Schwartz, Richard G. Kibbey, Benjamin F. Cravatt, Matthew P. Gillum

Proceedings of the National Academy of Sciences · 2019 · ▲ 56 citations

Altered intercellular communication Human Mouse
＋ Sign in to save

Abstract

Significance Deletion of fatty acid amide hydrolase (FAAH) in mice results in the concomitant elevation of 2 major types of fatty acid amides, N -acylethanolamines (NAEs) and N -acyl taurines (NATs), as well as obesity, hyperphagia, and insulin resistance. However, the respective contribution of each class of fatty acid amide to these phenotypes is unresolved. Here we employ an engineered variant of FAAH to specifically elevate NATs in vivo and administer the predominant circulating human NAT species to mice, demonstrating that NATs improve insulin sensitivity and augment secretion of the antidiabetic hormone GLP-1. These findings expose a divergent role for FAAH substrates in the regulation of glucose homeostasis, informing future efforts to target fatty acid amide signaling to treat metabolic disease.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source
OpenAlex
DOI
10.1073/pnas.1916288116
Canonical
link ↗
Fetched
2026-06-23 MST

Cite this

APA
Grevengoed, T.J., Trammell, S.A., McKinney, M.K., Petersen, N., Cardone, R., Svenningsen, J.S., Ogasawara, D., Nexøe-Larsen, C., Knop, F.K., Schwartz, T.W., Kibbey, R.G., Cravatt, B.F., &amp; Gillum, M.P. (2019). <i>N</i> -acyl taurines are endogenous lipid messengers that improve glucose homeostasis. <em>Proceedings of the National Academy of Sciences</em>. https://doi.org/10.1073/pnas.1916288116
Vancouver
Grevengoed TJ, Trammell SA, McKinney MK, Petersen N, Cardone R, Svenningsen JS, et al. <i>N</i> -acyl taurines are endogenous lipid messengers that improve glucose homeostasis. Proceedings of the National Academy of Sciences. 2019. doi:10.1073/pnas.1916288116.
BibTeX
@article{trisha2019iNiacy, title = {<i>N</i> -acyl taurines are endogenous lipid messengers that improve glucose homeostasis}, author = {Trisha J. Grevengoed and Samuel A.J. Trammell and Michele K. McKinney and Natalia Petersen and Rebecca Cardone and Jens S. Svenningsen and Daisuke Ogasawara and Christina Nexøe-Larsen and Filip K. Knop and Thue W. Schwartz and Richard G. Kibbey and Benjamin F. Cravatt and Matthew P. Gillum}, journal = {Proceedings of the National Academy of Sciences}, year = {2019}, doi = {10.1073/pnas.1916288116}, }

Research neighborhood

References, citing works, and semantically nearest findings. Click a node to open it.

Related findings