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Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice

Francesca Castoldi, Guido Kroemer, Federico Pietrocola

OncoImmunology · 2022 · ▲ 16 citations

Chronic inflammation Spermidine Human Mouse

Abstract

. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in aged patients.

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Provenance

Source: OpenAlex
DOI: 10.1080/2162402x.2022.2146855
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Fetched: 2026-06-18 MST

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APA

Castoldi, F., Kroemer, G., & Pietrocola, F. (2022). Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice. <em>OncoImmunology</em>. https://doi.org/10.1080/2162402x.2022.2146855

Vancouver

Castoldi F, Kroemer G, Pietrocola F. Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice. OncoImmunology. 2022. doi:10.1080/2162402x.2022.2146855.

BibTeX

@article{francesca2022Spermi, title = {Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice}, author = {Francesca Castoldi and Guido Kroemer and Federico Pietrocola}, journal = {OncoImmunology}, year = {2022}, doi = {10.1080/2162402x.2022.2146855}, }