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Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
Yueying Zhou, Xiaonan Xin, Lichao Wang, Binsheng Wang, Li Chen, Ousheng Liu, David W. Rowe, Ming Xu
npj Regenerative Medicine · 2021 · ▲ 86 citations
Cellular senescence
Stem-cell exhaustion
Stem-cell therapy
Senolytics
Cell culture / in vitro
Mouse
In vitro
Abstract
The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. D + Q might hold promise for improving BMSC function in aged populations.
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Provenance
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- OpenAlex
- DOI
- 10.1038/s41536-021-00145-z
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- 2026-06-15 MST
Cite this
APA
Zhou, Y., Xin, X., Wang, L., Wang, B., Chen, L., Liu, O., Rowe, D.W., & Xu, M. (2021). Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice. <em>npj Regenerative Medicine</em>. https://doi.org/10.1038/s41536-021-00145-z
Vancouver
Zhou Y, Xin X, Wang L, Wang B, Chen L, Liu O, et al. Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice. npj Regenerative Medicine. 2021. doi:10.1038/s41536-021-00145-z.
BibTeX
@article{yueying2021Senoly,
title = {Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice},
author = {Yueying Zhou and Xiaonan Xin and Lichao Wang and Binsheng Wang and Li Chen and Ousheng Liu and David W. Rowe and Ming Xu},
journal = {npj Regenerative Medicine},
year = {2021},
doi = {10.1038/s41536-021-00145-z},
}
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