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Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

Yueying Zhou, Xiaonan Xin, Lichao Wang, Binsheng Wang, Li Chen, Ousheng Liu, David W. Rowe, Ming Xu

npj Regenerative Medicine · 2021 · ▲ 90 citations

Cellular senescence Stem-cell exhaustion Senolytics Stem-cell therapy Cell culture / in vitro Mouse In vitro

Abstract

The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. D + Q might hold promise for improving BMSC function in aged populations.

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Provenance

Source: OpenAlex
DOI: 10.1038/s41536-021-00145-z
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Fetched: 2026-07-24 MST

Cite this

APA

Zhou, Y., Xin, X., Wang, L., Wang, B., Chen, L., Liu, O., Rowe, D.W., & Xu, M. (2021). Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice. <em>npj Regenerative Medicine</em>. https://doi.org/10.1038/s41536-021-00145-z

Vancouver

Zhou Y, Xin X, Wang L, Wang B, Chen L, Liu O, et al. Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice. npj Regenerative Medicine. 2021. doi:10.1038/s41536-021-00145-z.

BibTeX

@article{yueying2021Senoly, title = {Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice}, author = {Yueying Zhou and Xiaonan Xin and Lichao Wang and Binsheng Wang and Li Chen and Ousheng Liu and David W. Rowe and Ming Xu}, journal = {npj Regenerative Medicine}, year = {2021}, doi = {10.1038/s41536-021-00145-z}, }