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Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Christian Kempf, Jacquelyn M. Long, Piotr Laidler, Sanja Mijatović, Danijela Maksimović‐Ivanić, Franca Stivala, María Clorinda Mazzarino, Marco Donia, Paolo Fagone, Graziella Malaponte, Ferdinando Nicoletti, Massimo Libra

Aging · 2011 · ▲ 700 citations

Deregulated nutrient-sensing Cellular senescence Stem-cell exhaustion Altered intercellular communication Human Review

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Abstract

Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically associated with activation of these pro-survival pathways. This review discusses the functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli. Crosstalk and commonly identified mutations that occur within these pathways that contribute to abnormal activation and cancer growth will also be addressed. Finally the recently described roles of these pathways in cancer stem cells, cellular senescence and aging will be evaluated. Controlling the expression of these pathways could ameliorate human health.

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Provenance

Source: OpenAlex
DOI: 10.18632/aging.100296
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Fetched: 2026-06-13 MST

Cite this

APA

Steelman, L.S., Chappell, W.H., Abrams, S.L., Kempf, C., Long, J.M., Laidler, P., Mijatović, S., Maksimović‐Ivanić, D., Stivala, F., Mazzarino, M.C., Donia, M., Fagone, P., Malaponte, G., Nicoletti, F., Libra, M., Milella, M., Tafuri, A., Bonati, A., Bäsecke, J., & Cocco, L. (2011). Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. <em>Aging</em>. https://doi.org/10.18632/aging.100296

Vancouver

Steelman LS, Chappell WH, Abrams SL, Kempf C, Long JM, Laidler P, et al. Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging. 2011. doi:10.18632/aging.100296.

BibTeX

@article{linda2011Roleso, title = {Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging}, author = {Linda S. Steelman and William H. Chappell and Stephen L. Abrams and Christian Kempf and Jacquelyn M. Long and Piotr Laidler and Sanja Mijatović and Danijela Maksimović‐Ivanić and Franca Stivala and María Clorinda Mazzarino and Marco Donia and Paolo Fagone and Graziella Malaponte and Ferdinando Nicoletti and Massimo Libra and Michèle Milella and Agostino Tafuri and Antonio Bonati and Jörg Bäsecke and Lucio Cocco and Camilla Evangelisti and Alberto M. Martelli and Giuseppe Montalto and Melchiorre Cervello and James A. McCubrey}, journal = {Aging}, year = {2011}, doi = {10.18632/aging.100296}, }