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Pomegranate juice and extract extended lifespan and reduced intestinal fat deposition in Caenorhabditis elegans

Jolene Zheng, David Heber, Mingming Wang, Chenfei Gao, Steven B. Heymsfield, Roy Joseph Martin, Frank L. Greenway, John W. Finley, Jeffrey H. Burton, William D. Johnson, Frederick M. Enright, Michael J. Keenan, Zhaoping Li

International Journal for Vitamin and Nutrition Research · 2017 · ▲ 23 citations

Deregulated nutrient-sensing C. elegans Human Drosophila

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Abstract

Abstract. Pomegranate juice with a high content of polyphenols, pomegranate extract, ellagic acid, and urolithin A, have anti-oxidant and anti-obesity effects in humans. Pomegranate juice extends lifespan of Drosophila melanogaster. Caenorhabditis elegans (C. elegans) (n = 6) compared to the control group in each treatment, lifespan was increased by pomegranate juice in wild type (N2, 56 %, P < 0.001) and daf-16 mutant (daf-16(mgDf50)I) (18 %, P = 0.00012), by pomegranate extract in N2 (28 %, P = 0.00004) and in daf-16(mgDf50)I (10 %, P < 0.05), or by ellagic acid (11 %, P < 0.05). Pomegranate juice reduced intestinal fat deposition (IFD) in C. elegans (n = 10) N2 (–68 %, P = 0.0003) or in the daf-16(mgDf50)I (–33 %, P = 0.0034). The intestinal fat deposition was increased by pomegranate extract in N2 (137 %, P < 0.0138) and in daf-16(mgDf50)I (26 %, P = 0.0225), by ellagic acid in N2 (66 %, P < 0.0001) and in daf-16(mgDf50)I (74 %, P < 0.0001), or by urolithin A in N2 (57 %, P = 0.0039) and in daf-16(mgDf50)I (43 %, P = 0.0001). These effects were partially mediated by the daf-16 pathway. The data may offer insights to human aging and obesity due to homology with C. elegans.

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Provenance

Source: OpenAlex
DOI: 10.1024/0300-9831/a000570
Canonical: link ↗
Fetched: 2026-10-12 MST

Cite this

APA

Zheng, J., Heber, D., Wang, M., Gao, C., Heymsfield, S.B., Martin, R.J., Greenway, F.L., Finley, J.W., Burton, J.H., Johnson, W.D., Enright, F.M., Keenan, M.J., & Li, Z. (2017). Pomegranate juice and extract extended lifespan and reduced intestinal fat deposition in Caenorhabditis elegans. <em>International Journal for Vitamin and Nutrition Research</em>. https://doi.org/10.1024/0300-9831/a000570

Vancouver

Zheng J, Heber D, Wang M, Gao C, Heymsfield SB, Martin RJ, et al. Pomegranate juice and extract extended lifespan and reduced intestinal fat deposition in Caenorhabditis elegans. International Journal for Vitamin and Nutrition Research. 2017. doi:10.1024/0300-9831/a000570.

BibTeX

@unpublished{jolene2017Pomegr, title = {Pomegranate juice and extract extended lifespan and reduced intestinal fat deposition in Caenorhabditis elegans}, author = {Jolene Zheng and David Heber and Mingming Wang and Chenfei Gao and Steven B. Heymsfield and Roy Joseph Martin and Frank L. Greenway and John W. Finley and Jeffrey H. Burton and William D. Johnson and Frederick M. Enright and Michael J. Keenan and Zhaoping Li}, journal = {International Journal for Vitamin and Nutrition Research}, year = {2017}, doi = {10.1024/0300-9831/a000570}, }