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Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

Samuel A.J. Trammell, Mark S. Schmidt, Benjamin J. Weidemann, Philip Redpath, Frank Jaksch, Ryan W. Dellinger, Zhonggang Li, E. Dale Abel, Marie E. Migaud, Charles Brenner

Nature Communications · 2016 · ▲ 714 citations

Deregulated nutrient-sensing Human Mouse

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Abstract

Abstract Nicotinamide riboside (NR) is in wide use as an NAD + precursor vitamin. Here we determine the time and dose-dependent effects of NR on blood NAD + metabolism in humans. We report that human blood NAD + can rise as much as 2.7-fold with a single oral dose of NR in a pilot study of one individual, and that oral NR elevates mouse hepatic NAD + with distinct and superior pharmacokinetics to those of nicotinic acid and nicotinamide. We further show that single doses of 100, 300 and 1,000 mg of NR produce dose-dependent increases in the blood NAD + metabolome in the first clinical trial of NR pharmacokinetics in humans. We also report that nicotinic acid adenine dinucleotide (NAAD), which was not thought to be en route for the conversion of NR to NAD + , is formed from NR and discover that the rise in NAAD is a highly sensitive biomarker of effective NAD + repletion.

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Provenance

Source: OpenAlex
DOI: 10.1038/ncomms12948
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Fetched: 2026-07-23 MST

Cite this

APA

Trammell, S.A., Schmidt, M.S., Weidemann, B.J., Redpath, P., Jaksch, F., Dellinger, R.W., Li, Z., Abel, E.D., Migaud, M.E., & Brenner, C. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. <em>Nature Communications</em>. https://doi.org/10.1038/ncomms12948

Vancouver

Trammell SA, Schmidt MS, Weidemann BJ, Redpath P, Jaksch F, Dellinger RW, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications. 2016. doi:10.1038/ncomms12948.

BibTeX

@article{samuel2016Nicoti, title = {Nicotinamide riboside is uniquely and orally bioavailable in mice and humans}, author = {Samuel A.J. Trammell and Mark S. Schmidt and Benjamin J. Weidemann and Philip Redpath and Frank Jaksch and Ryan W. Dellinger and Zhonggang Li and E. Dale Abel and Marie E. Migaud and Charles Brenner}, journal = {Nature Communications}, year = {2016}, doi = {10.1038/ncomms12948}, }