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NAD + supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING

Yujun Hou, Yong Quek Wei, Sofie Lautrup, Beimeng Yang, Yue Wang, Stephanie A. Cordonnier, Mark P. Mattson, Deborah L. Croteau, Vilhelm A. Bohr

Proceedings of the National Academy of Sciences · 2021 · ▲ 542 citations

Genomic instability Cellular senescence Chronic inflammation Mouse

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Abstract

Significance Impaired neuronal bioenergetics and neuroinflammation are thought to play key roles in the progression of Alzheimer's disease (AD), but their interplay is not clear. AD mouse brains showed lower nicotinamide adenine dinucleotide (NAD + ) levels and alterations in inflammation. Treatment of AD mice with NR reduced neuroinflammation, attenuated DNA damage, and prevented cellular senescence. We present evidence that the beneficial effects of nicotinamide riboside (NR) are, in part, through a cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING)-dependent pathway. DNA damage was increased in AD and attenuated by NR. Both cGAS–STING and NAD + pathways are potential therapeutic targets for AD.

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Provenance

Source: OpenAlex
DOI: 10.1073/pnas.2011226118
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Fetched: 2026-10-01 MST

Cite this

APA

Hou, Y., Wei, Y.Q., Lautrup, S., Yang, B., Wang, Y., Cordonnier, S.A., Mattson, M.P., Croteau, D.L., & Bohr, V.A. (2021). NAD + supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING. <em>Proceedings of the National Academy of Sciences</em>. https://doi.org/10.1073/pnas.2011226118

Vancouver

Hou Y, Wei YQ, Lautrup S, Yang B, Wang Y, Cordonnier SA, et al. NAD + supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING. Proceedings of the National Academy of Sciences. 2021. doi:10.1073/pnas.2011226118.

BibTeX

@unpublished{yujun2021NADsup, title = {NAD + supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING}, author = {Yujun Hou and Yong Quek Wei and Sofie Lautrup and Beimeng Yang and Yue Wang and Stephanie A. Cordonnier and Mark P. Mattson and Deborah L. Croteau and Vilhelm A. Bohr}, journal = {Proceedings of the National Academy of Sciences}, year = {2021}, doi = {10.1073/pnas.2011226118}, }