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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence

Vladimir N. Anisimov, L. E. Bakeeva, Peter A. Egormin, О. Ф. Филенко, Е. Ф. Исакова, В. Н. Манских, V. M. Mikhelson, Alisa A. Panteleeva, E. G. Pasyukova, D. I. Pilipenko, Tatiana S. Piskunova, Irina G. Popovich, Н. В. Рощина, Olga Y. Rybina, V. B. Saprunova

Biochemistry (Moscow) · 2008 · ▲ 112 citations

Mitochondrial dysfunction Cellular senescence Mouse Drosophila

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Abstract

Very low (nano- and subnanomolar) concentrations of 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong lifespan of a fungus (Podospora anserina), a crustacean (Ceriodaphnia affinis), an insect (Drosophila melanogaster), and a mammal (mouse). In the latter case, median lifespan is doubled if animals live in a non-sterile vivarium. The lifespan increase is accompanied by rectangularization of the survival curves (an increase in survival is much larger at early than at late ages) and disappearance of typical traits of senescence or retardation of their development. Data summarized here and in the preceding papers of this series suggest that mitochondria-targeted antioxidant SkQ1 is competent in slowing down execution of an aging program responsible for development of age-related senescence.

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Provenance

Source: OpenAlex
DOI: 10.1134/s0006297908120055
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Fetched: 2026-06-30 MST

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APA

Anisimov, V.N., Bakeeva, L.E., Egormin, P.A., Филенко, �.�., Исакова, �.�., Манских, �.�., Mikhelson, V.M., Panteleeva, A.A., Pasyukova, E.G., Pilipenko, D.I., Piskunova, T.S., Popovich, I.G., Рощина, �.�., Rybina, O.Y., Saprunova, V.B., Samoylova, T.A., Semenchenko, A.V., Skulachev, M.V., Im, S., & Tsybul’ko, E.A. (2008). Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence. <em>Biochemistry (Moscow)</em>. https://doi.org/10.1134/s0006297908120055

Vancouver

Anisimov VN, Bakeeva LE, Egormin PA, Филенко ��, Исакова ��, Манских ��, et al. Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence. Biochemistry (Moscow). 2008. doi:10.1134/s0006297908120055.

BibTeX

@article{vladimir2008Mitoch, title = {Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence}, author = {Vladimir N. Anisimov and L. E. Bakeeva and Peter A. Egormin and О. Ф. Филенко and Е. Ф. Исакова and В. Н. Манских and V. M. Mikhelson and Alisa A. Panteleeva and E. G. Pasyukova and D. I. Pilipenko and Tatiana S. Piskunova and Irina G. Popovich and Н. В. Рощина and Olga Y. Rybina and V. B. Saprunova and T. A. Samoylova and Anna V. Semenchenko and Maxim V. Skulachev and Spivak Im and E. A. Tsybul’ko and Margarita L. Tyndyk and M. Yu. Vyssokikh and M. N. Yurova and Mark A. Zabezhinsky and Vladimir P. Skulachev}, journal = {Biochemistry (Moscow)}, year = {2008}, doi = {10.1134/s0006297908120055}, }