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Mammalian Sirt1: insights on its biological functions

Cell Communication and Signaling · 2011 · ▲ 361 citations

Deregulated nutrient-sensing Cellular senescence Altered intercellular communication Chronic inflammation Review

Abstract

Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. Sirt1 performs a wide variety of functions in biological systems. The current review focuses on the biological functions of Sirt1 in obesity-associated metabolic diseases, cancer, adipose tissue, aging, cellular senescence, cardiac aging and stress, prion-mediated neurodegeneration, inflammatory signaling in response to environmental stress, development and placental cell survival.

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Provenance

Source: OpenAlex
DOI: 10.1186/1478-811x-9-11
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Fetched: 2026-10-23 MST

Cite this

APA

Rahman, S., & Islam, R. (2011). Mammalian Sirt1: insights on its biological functions. <em>Cell Communication and Signaling</em>. https://doi.org/10.1186/1478-811x-9-11

Vancouver

Rahman S, Islam R. Mammalian Sirt1: insights on its biological functions. Cell Communication and Signaling. 2011. doi:10.1186/1478-811x-9-11.

BibTeX

@article{shahedur2011Mammal, title = {Mammalian Sirt1: insights on its biological functions}, author = {Shahedur Rahman and Rezuanul Islam}, journal = {Cell Communication and Signaling}, year = {2011}, doi = {10.1186/1478-811x-9-11}, }