Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19

Inflammaging(definition) constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence(definition), and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction opens the field for new therapeutic strategies to prevent severe COVID-19. Immunometabolism-mediated approaches such as mTOR(definition)-inhibiting drug studied for extending healthspan and lifespan." style="text-decoration:underline dotted; text-underline-offset:2px; cursor:help;">rapamycin(definition), metformin and dimethyl fumarate, may optimize COVID-19 treatment of the elderly and patients at risk for severe disease.