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Ginsenoside-Re-rich ethanol extract of Panax ginseng berry enhances healthspan extension via mitostasis and NAD metabolism.

Kim M, Kim SH, Kim J, Jin EJ, Wei S, Jo Y, Oh CM, Ha KT, Roh JH, Kim WG, Cho D, Choi YJ, Jung SM, Ryu D.

Journal of ginseng research · 2025 · ▲ 4 citations

Mitochondrial dysfunction Disabled macroautophagy Exercise C. elegans Mouse
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Abstract

<h4>Background</h4>Ginseng Berry Concentrate (GBC) enhances exercise capacity in mice, but the effects of its key component, ginsenoside Re (G-Re), on aging and mitochondrial function are not well understood. This study investigates the impact of G-Re on mitophagy and its potential to promote healthy aging.<h4>Methods</h4>Experiments in C2C12 myocytes and HeLa-mitoKeima-PARKIN cells assessed GBC and G-Re's effects on mitophagy, supported by Gene Set Enrichment Analysis. G-Re was identified as the primary component of GBC via high-performance liquid chromatography. The influence of G-Re on lifespan and healthspan(definition) was examined in <i>Caenorhabditis elegans</i>, with a focus on mitophagy pathways.<h4>Results</h4>GBC and G-Re significantly induced mitophagy and enhanced mitochondrial gene expression, improving mitochondrial function. G-Re extended lifespan and healthspan in <i>C. elegans</i>, effects absent in mitophagy-impaired mutants.<h4>Conclusion</h4>G-Re enhances mitochondrial function and promotes healthy aging through mitophagy, suggesting its potential for mitigating age-related functional declines.

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Provenance

Source
Europe PMC
DOI
10.1016/j.jgr.2024.11.002
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Fetched
2026-05-31 MST

Cite this

APA
M, K., SH, K., J, K., EJ, J., S, W., Y, J., CM, O., KT, H., JH, R., WG, K., D, C., YJ, C., SM, J., &amp; D., R. (2025). Ginsenoside-Re-rich ethanol extract of Panax ginseng berry enhances healthspan extension via mitostasis and NAD metabolism. <em>Journal of ginseng research</em>. https://doi.org/10.1016/j.jgr.2024.11.002
Vancouver
M K, SH K, J K, EJ J, S W, Y J, et al. Ginsenoside-Re-rich ethanol extract of Panax ginseng berry enhances healthspan extension via mitostasis and NAD metabolism. Journal of ginseng research. 2025. doi:10.1016/j.jgr.2024.11.002.
BibTeX
@article{kim2025Ginsen, title = {Ginsenoside-Re-rich ethanol extract of Panax ginseng berry enhances healthspan extension via mitostasis and NAD metabolism.}, author = {Kim M and Kim SH and Kim J and Jin EJ and Wei S and Jo Y and Oh CM and Ha KT and Roh JH and Kim WG and Cho D and Choi YJ and Jung SM and Ryu D.}, journal = {Journal of ginseng research}, year = {2025}, doi = {10.1016/j.jgr.2024.11.002}, }

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