Faculty Opinions recommendation of Young blood plasma reduces Alzheimer's disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice.

Background: Recent studies indicated that circulatory factors in blood plasma from young animals can reactivate neurogenesis, restore synaptic plasticity, and improve cognitive function in aged animals. Here, we investigated if young plasma could have a possible therapeutic effect for treatment of Alzheimer's disease (AD)-like pathologies and cognitive impairment in triple-transgenic AD (3Tg-AD) mice. Methods: We intravenously injected plasma from 2-to 3-month-old C57BL/6 J wild-type mice into 16-17-monthold 3Tg-AD mice twice a week for 8 weeks. The behavioral tests including open field, novel object recognition, Morris water maze, and reversal Morris water maze were conducted after 4-week plasma injections. The effect of young plasma on tau and A pathologies and on the levels of synaptic proteins and neuroinflammation were assessed by Western blots and immunohistochemical staining.