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Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice

Randy Strong, James F. Nelson, Molly A. Bogue, Jerry R. Colca, Martin S. Denzel, Vivian Diaz, Brian N. Finck, Vadim N. Gladyshev, Steve Horvath, Nisi Jiang, Tracy Keller, Rolf F. Kletzien, Ron Korstanje, Navasuja Kumar, Christiaan Leeuwenburgh

GeroScience · 2025 · ▲ 5 citations

Deregulated nutrient-sensing Mouse

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Abstract

Mice bred in 2021 were tested by the Interventions Testing Program (ITP) for possible lifespan benefits of 2BAct (2BA), dichloroacetate (DCA), Epicatechin (EPI), Forskolin (FSK), Halofuginone (HAL) and Mitoglitazone (MIT). All agents were administered in the diet ad libitum beginning at 7 months of age. In male mice, EPI increased median lifespan by ~ 5%, and HAL and MIT each increased median lifespan by ~ 9%. EPI and HAL, but not MIT, increased 90% survival. In addition to adding 3 new agents to the list of interventions identified by the ITP that extend lifespan, this report continues the strong male bias in the efficacy of life-extending drugs identified so far.

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Provenance

Source: OpenAlex
DOI: 10.1007/s11357-025-01881-6
Canonical: link ↗
Fetched: 2026-08-04 MST

Cite this

APA

Strong, R., Nelson, J.F., Bogue, M.A., Colca, J.R., Denzel, M.S., Diaz, V., Finck, B.N., Gladyshev, V.N., Horvath, S., Jiang, N., Keller, T., Kletzien, R.F., Korstanje, R., Kumar, N., Leeuwenburgh, C., Fernández, E., Gałecki, A.T., Ginsburg, B.C., Han, M., & Kaczorowski, C.C. (2025). Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice. <em>GeroScience</em>. https://doi.org/10.1007/s11357-025-01881-6

Vancouver

Strong R, Nelson JF, Bogue MA, Colca JR, Denzel MS, Diaz V, et al. Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice. GeroScience. 2025. doi:10.1007/s11357-025-01881-6.

BibTeX

@article{randy2025Extens, title = {Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice}, author = {Randy Strong and James F. Nelson and Molly A. Bogue and Jerry R. Colca and Martin S. Denzel and Vivian Diaz and Brian N. Finck and Vadim N. Gladyshev and Steve Horvath and Nisi Jiang and Tracy Keller and Rolf F. Kletzien and Ron Korstanje and Navasuja Kumar and Christiaan Leeuwenburgh and Elizabeth Fernández and Andrzej T. Gałecki and Brett C. Ginsburg and Melissa Han and Catherine C. Kaczorowski and Scott F. Leiser and Marisa Lopez‐Cruzan and Ken Raj and Peter C. Reifsnyder and Nadia Rosenthal}, journal = {GeroScience}, year = {2025}, doi = {10.1007/s11357-025-01881-6}, }