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Dynamic force sensing by bone delays aging and extends lifespan.

Zhang Z, Cai Z, Liu S, Chu Y, Jiang Z, Zhang W, Pan Y, Lin Y, Wei X, Chen J, Huangfu J, Nan B, Zhou Y, Hu L, Liang W

Cell metabolism · 2026

Cellular senescence Chronic inflammation Exercise Human Mouse

Abstract

Physical activity promotes health primarily by decelerating the aging process. Bone is one of the tissues capable of sensing mechanical force and can adapt to different physical demands. However, its role in whole-body aging is unknown. We found that reduced mechano-sensing in osteocytes, caused by deletion of the mechanosensory channel, Piezo1, accelerated whole-body aging in mice. Dynamic tibial axial loading (DTAL) in mice at 20-24 months of age extended both healthspan and lifespan (9.4%/79.5 days). Furthermore, DTAL reversed bone marrow immunosenescence and induced anti-aging and protective factors while downregulating pro-aging and pro-inflammatory factors. We also identified pigment epithelium-derived factor (PEDF) as a novel mechano-responsive anti-aging factor that is highly associated with healthy aging in humans. Thus, our findings highlighted an essential role for bone mechano-sensing in whole-body aging. This could potentially be manipulated to prevent aging, extend health, and aid those unable to exercise or with decreased mobility.

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Provenance

Source: Europe PMC
DOI: 10.1016/j.cmet.2026.09.020
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Fetched: 2026-10-25 MST

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APA

Z, Z., Z, C., S, L., Y, C., Z, J., W, Z., Y, P., Y, L., X, W., J, C., J, H., B, N., Y, Z., L, H., W, L., Z, Z., M, H., S, L., D, L., & X., B. (2026). Dynamic force sensing by bone delays aging and extends lifespan. <em>Cell metabolism</em>. https://doi.org/10.1016/j.cmet.2026.09.020

Vancouver

Z Z, Z C, S L, Y C, Z J, W Z, et al. Dynamic force sensing by bone delays aging and extends lifespan. Cell metabolism. 2026. doi:10.1016/j.cmet.2026.09.020.

BibTeX

@article{zhang2026Dynami, title = {Dynamic force sensing by bone delays aging and extends lifespan.}, author = {Zhang Z and Cai Z and Liu S and Chu Y and Jiang Z and Zhang W and Pan Y and Lin Y and Wei X and Chen J and Huangfu J and Nan B and Zhou Y and Hu L and Liang W and Zou Z and Huang M and Lu S and Lu D and Bai X.}, journal = {Cell metabolism}, year = {2026}, doi = {10.1016/j.cmet.2026.09.020}, }