Clinical Study of the Effect of Bushen Zhuanggu Powder on Bone Transformation in Aged Males with Osteoporosis

Objective:To observe the curative effect of Bushen Zhuanggu Powder (BZP) on senile osteoporosis, and to study its advantages and shortages.Methods:One hundred and twenty senile osteoporosis patients were randomized into treating group of BZP and control groups of Xianlinggubao, Guijianggaisu, and Gubang, and the therapy lasted half a year. The following indicators were determined before and after using these drugs, such as bone mineral density (BMD), serum tartrate-resistant acid phosphatase-5b (TRACP-5b), bone specificity alkaline phosphatase (BAP), and N-MID osteocalcin (N-MID OT). Results:In BZP group, the level of serum TRACP-5b decreased significantly, while BAP and BMD were remarkably increased (P0.05), but there was no obvious change of N-MID OT (P0.05). The levels of BAP and serum TRACP-5b in BZP group were improved more obviously than in Xianlinggubao group (P0.05), but not the level of N-MID OT. No apparent difference was found in BMD between the two groups (P0.05). Compared to Guijianggaisu group, BMD was obviously elevated in BZP group (P0.05), but there was no significant differences in TRACP-5b, BAP and N-MID OT (P0.05). There was more obvious improvement in BAP in Gubang group than in BZP group (P0.05), but there were no significant differences in the rest indicators between the two groups (P0.05). Conclusion:Bushen Zhuanggu powder, Xianlinggubao, Guijianggaisu, Gubang can promote bone formation, inhibit bone resorption, and elevate bone density while used with calcium and activated vitamin D. BZP can promote bone formation more obviously than Xianlinggubao, and elevate bone density more obviously than Guijianggaisu, but is inferior to Gubang in promoting bone formation.