Study on the relationship between bone metabolism indexes and osteoporosis in aged males

Objective To investigate the characteristics and significance of the changes of bone metabolism indexes related to the occurence of osteoporosis in aged males. Methods Serum interleukine 1β(IL 1β),insulin like growth factorⅡ(IGF Ⅱ),parathyroid hormone(PTH M) and 25 OH D were measured by radioimmunoassay in 58 aged males with osteoporosis and 37 cases with bone mass loss. Bone density was measured in these subjects and all the indexes were compared with those in young and middle aged and aged healthy controls. Results IL 1β and PTH M levels in aged males with osteoporosis or bone mass loss were higher than those in healthy controls( P 0.01), while IGF Ⅱ and 25 OH D were lower than in normal controls, especially in osteoporosis group ( P 0.01). With the age increasing and the deterioration of the disorder, bone density in the two groups of patients were significantly lower than those in young and middle aged controls ( P 0.01). Aged males with osteoporosis had a significantly lower bone density than patients with bone mass loss. Conclusion Cytokines and disturbance of bone metabolism indexes are the main factors that lead to osteoporosis characterized by more bone absorption and less bone formation in aged males.