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Bmi1, stem cells, and senescence regulation

In-Kyung Park, Sean J. Morrison, Michael F. Clarke

Journal of Clinical Investigation · 2004 · ▲ 443 citations

Cellular senescence Stem-cell exhaustion

Abstract

Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.

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Provenance

Source: OpenAlex
DOI: 10.1172/jci20800
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Fetched: 2026-05-31 MST

Cite this

APA

Park, I., Morrison, S.J., & Clarke, M.F. (2004). Bmi1, stem cells, and senescence regulation. <em>Journal of Clinical Investigation</em>. https://doi.org/10.1172/jci20800

Vancouver

Park I, Morrison SJ, Clarke MF. Bmi1, stem cells, and senescence regulation. Journal of Clinical Investigation. 2004. doi:10.1172/jci20800.

BibTeX

@unpublished{inkyung2004Bmiste, title = {Bmi1, stem cells, and senescence regulation}, author = {In-Kyung Park and Sean J. Morrison and Michael F. Clarke}, journal = {Journal of Clinical Investigation}, year = {2004}, doi = {10.1172/jci20800}, }