Open access · OA via OpenAlex

Bmi1, stem cells, and senescence regulation

Inkyung Park, Sean J. Morrison, Michael F. Clarke

Journal of Clinical Investigation · 2004 · ▲ 421 citations

Cellular senescence Stem-cell exhaustion

Abstract

Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.1172/jci200420800
Canonical: link ↗
Fetched: 2026-05-31 MST

Cite this

APA

Park, I., Morrison, S.J., & Clarke, M.F. (2004). Bmi1, stem cells, and senescence regulation. <em>Journal of Clinical Investigation</em>. https://doi.org/10.1172/jci200420800

Vancouver

Park I, Morrison SJ, Clarke MF. Bmi1, stem cells, and senescence regulation. Journal of Clinical Investigation. 2004. doi:10.1172/jci200420800.

BibTeX

@article{inkyung2004Bmiste, title = {Bmi1, stem cells, and senescence regulation}, author = {Inkyung Park and Sean J. Morrison and Michael F. Clarke}, journal = {Journal of Clinical Investigation}, year = {2004}, doi = {10.1172/jci200420800}, }