Preprint · CC-BY via OpenAlex

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

Jing Zhao, Lei Justan Zhang, Aiping Lu, Yingchao Han, Debora Colangelo, Christina Bukata, Alex C. Scibetta, Matthew J. Yousefzadeh, Xuesen Li, Aditi U. Gurkar, Sara J. McGowan, Luise A. Angelini, Ryan D. O'Kelly, Hongshuai Li, Lana Corbo

Aging · 2020 · ▲ 121 citations

Genomic instability Cellular senescence Stem-cell exhaustion Mouse

＋ Sign in to save

Abstract

mice with the ATM inhibitor KU-55933 suppressed markers of senescence and SASP. Taken together, these results demonstrate that the ATM kinase is a major mediator of DNA damage-induced, NF-κB-mediated cellular senescence, stem cell dysfunction and aging and thus represents a therapeutic target to slow the progression of aging.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.18632/aging.102863
Canonical: link ↗
Fetched: 2026-09-29 MST

Cite this

APA

Zhao, J., Zhang, L.J., Lu, A., Han, Y., Colangelo, D., Bukata, C., Scibetta, A.C., Yousefzadeh, M.J., Li, X., Gurkar, A.U., McGowan, S.J., Angelini, L.A., O'Kelly, R.D., Li, H., Corbo, L., Sano, T., Nick, H., Pola, E., Pilla, S.P., & Ladiges, W. (2020). ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. <em>Aging</em>. https://doi.org/10.18632/aging.102863

Vancouver

Zhao J, Zhang LJ, Lu A, Han Y, Colangelo D, Bukata C, et al. ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. Aging. 2020. doi:10.18632/aging.102863.

BibTeX

@unpublished{jing2020ATMisa, title = {ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging}, author = {Jing Zhao and Lei Justan Zhang and Aiping Lu and Yingchao Han and Debora Colangelo and Christina Bukata and Alex C. Scibetta and Matthew J. Yousefzadeh and Xuesen Li and Aditi U. Gurkar and Sara J. McGowan and Luise A. Angelini and Ryan D. O'Kelly and Hongshuai Li and Lana Corbo and Tokio Sano and Heather Nick and Enrico Pola and Smitha P.S. Pilla and Warren Ladiges and Nam N. Vo and Johnny Huard and Laura J. Niedernhofer and Paul D. Robbins}, journal = {Aging}, year = {2020}, doi = {10.18632/aging.102863}, }