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Apoptotic vesicle-mediated senolytics requires mechanical loading

Zhulin Xue, Yexiang Jiang, Bowen Meng, Lu Lu, Hao Meng, Yi Zhang, Songtao Shi, Zili Li, Xueli Mao

Theranostics · 2024 · ▲ 14 citations

Cellular senescence Stem-cell exhaustion Senolytics Stem-cell therapy Mouse

Abstract

This study identified a previously unknown role of mechanical force in maintaining apoptotic homeostasis and eliminating senescent cells. Systemic infusion of mesenchymal stem cell-derived apoVs can effectively rescue apoptotic resistance and eliminate senescent cells in mechanical unloading mice.

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Provenance

Source: OpenAlex
DOI: 10.7150/thno.98763
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Fetched: 2026-08-01 MST

Cite this

APA

Xue, Z., Jiang, Y., Meng, B., Lu, L., Meng, H., Zhang, Y., Shi, S., Li, Z., & Mao, X. (2024). Apoptotic vesicle-mediated senolytics requires mechanical loading. <em>Theranostics</em>. https://doi.org/10.7150/thno.98763

Vancouver

Xue Z, Jiang Y, Meng B, Lu L, Meng H, Zhang Y, et al. Apoptotic vesicle-mediated senolytics requires mechanical loading. Theranostics. 2024. doi:10.7150/thno.98763.

BibTeX

@article{zhulin2024Apopto, title = {Apoptotic vesicle-mediated senolytics requires mechanical loading}, author = {Zhulin Xue and Yexiang Jiang and Bowen Meng and Lu Lu and Hao Meng and Yi Zhang and Songtao Shi and Zili Li and Xueli Mao}, journal = {Theranostics}, year = {2024}, doi = {10.7150/thno.98763}, }