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An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in Humans

Nazish Sayed, Tianxiang Gao, Robert Tibshirani, Trevor Hastie, Lu Cui, Tatiana Kuznetsova, Yael Rosenberg‐Hasson, Rita Ostan, Daniela Monti, Benoit Lehallier, Shai S. Shen-Orr, Holden T. Maecker, Cornelia L. Dekker, Tony Wyss‐Coray, Claudio Franceschi

bioRxiv (Cold Spring Harbor Laboratory) · 2019 · ▲ 14 citations

Deregulated nutrient-sensing Cellular senescence Chronic inflammation Human

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Abstract

Abstract While many diseases of aging have been linked to the immunological system, immune metrics with which to identify the most at-risk individuals are lacking. Here, we studied the blood immunome of 1001 individuals age 8-96 and derived an inflammatory clock of aging (iAge), which tracked with multi-morbidity and immunosenescence. In centenarians, iAge was on average, 40 years lower than their corresponding chronological age. The strongest contributor to this metric was the chemokine CXCL9, which was involved in cardiac aging, affected vascular function, and down-regulated Sirtuin-3, a longevity-associated molecule. Thus, our results identify an important link between inflammatory molecules and pathways known to govern lifespan.

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Provenance

Source: OpenAlex
DOI: 10.1101/840363
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Fetched: 2026-07-25 MST

Cite this

APA

Sayed, N., Gao, T., Tibshirani, R., Hastie, T., Cui, L., Kuznetsova, T., Rosenberg‐Hasson, Y., Ostan, R., Monti, D., Lehallier, B., Shen-Orr, S.S., Maecker, H.T., Dekker, C.L., Wyss‐Coray, T., Franceschi, C., Jojic, V., Haddad, F., Montoya, J.G., Wu, J.C., & Furman, D. (2019). An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in Humans. <em>bioRxiv (Cold Spring Harbor Laboratory)</em>. https://doi.org/10.1101/840363

Vancouver

Sayed N, Gao T, Tibshirani R, Hastie T, Cui L, Kuznetsova T, et al. An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in Humans. bioRxiv (Cold Spring Harbor Laboratory). 2019. doi:10.1101/840363.

BibTeX

@unpublished{nazish2019AnInfl, title = {An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in Humans}, author = {Nazish Sayed and Tianxiang Gao and Robert Tibshirani and Trevor Hastie and Lu Cui and Tatiana Kuznetsova and Yael Rosenberg‐Hasson and Rita Ostan and Daniela Monti and Benoit Lehallier and Shai S. Shen-Orr and Holden T. Maecker and Cornelia L. Dekker and Tony Wyss‐Coray and Claudio Franceschi and Vladimir Jojic and François Haddad and José G. Montoya and Joseph C. Wu and David Furman}, journal = {bioRxiv (Cold Spring Harbor Laboratory)}, year = {2019}, doi = {10.1101/840363}, }