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Aging of the neural stem cell niche: integration of local and muscle-derived systemic signals in preclinical and translational contexts

Weiyi Jiang, Kenon Chua, Hiang Khoon Tan, Eng King Tan, Kun‐Yang Lin, Hong-Wen Tang

npj Aging · 2026

Stem-cell exhaustion Chronic inflammation Exercise Plasma dilution / young plasma Human Preclinical / animal

Abstract

Aging weakens neural stem cell (NSC) function and reduces brain plasticity, but this process is shaped by more than the brain alone. Local niche cells become disrupted with age and inflammation, while skeletal muscle sends systemic signals through myokines, metabolites, and vascular interfaces. Evidence from exercise, parabiosis, and rejuvenation studies suggests that preserving muscle health may help protect NSC niches and brain regenerative capacity.

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Provenance

Source: OpenAlex
DOI: 10.1038/s41514-026-00468-5
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Fetched: 2026-08-04 MST

Cite this

APA

Jiang, W., Chua, K., Tan, H.K., Tan, E.K., Lin, K., & Tang, H. (2026). Aging of the neural stem cell niche: integration of local and muscle-derived systemic signals in preclinical and translational contexts. <em>npj Aging</em>. https://doi.org/10.1038/s41514-026-00468-5

Vancouver

Jiang W, Chua K, Tan HK, Tan EK, Lin K, Tang H. Aging of the neural stem cell niche: integration of local and muscle-derived systemic signals in preclinical and translational contexts. npj Aging. 2026. doi:10.1038/s41514-026-00468-5.

BibTeX

@article{weiyi2026Agingo, title = {Aging of the neural stem cell niche: integration of local and muscle-derived systemic signals in preclinical and translational contexts}, author = {Weiyi Jiang and Kenon Chua and Hiang Khoon Tan and Eng King Tan and Kun‐Yang Lin and Hong-Wen Tang}, journal = {npj Aging}, year = {2026}, doi = {10.1038/s41514-026-00468-5}, }