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Acetyl-CoA carboxylase 1–dependent lipogenesis promotes autophagy downstream of AMPK

Angelina S. Gross, Andreas Zimmermann, Tobias Pendl, Sabrina Schroeder, Hannes Schoenlechner, Oskar Knittelfelder, Laura Lamplmayr, Ana Santiso, Andreas Aufschnaiter, Daniel Waltenstorfer, Sandra Ortonobes Lara, Sarah Stryeck, Christina Kast, Christoph Ruckenstuhl, Sebastian J. Hofer

Journal of Biological Chemistry · 2019 · ▲ 56 citations

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Abstract

Instead, administration of oleate, while mimicking constitutively active Acc1 in WT cells, alleviates the vacuolar fusion defects induced by Acc1 inhibition. Our results argue for a largely lipid-dependent process of autophagy regulation downstream of Acc1. We present a versatile genetic model to investigate the complex relationship between acetate metabolism, lipid homeostasis, and autophagy and propose Acc1-dependent lipogenesis as a fundamental metabolic path downstream of Snf1 to maintain autophagy and survival during cellular aging.

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Provenance

Source: OpenAlex
DOI: 10.1074/jbc.ra118.007020
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Fetched: 2026-06-16 MST

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APA

Gross, A.S., Zimmermann, A., Pendl, T., Schroeder, S., Schoenlechner, H., Knittelfelder, O., Lamplmayr, L., Santiso, A., Aufschnaiter, A., Waltenstorfer, D., Lara, S.O., Stryeck, S., Kast, C., Ruckenstuhl, C., Hofer, S.J., Michelitsch, B., Woelflingseder, M., Müller, R., Carmona‐Gutiérrez, D., & Madl, T. (2019). Acetyl-CoA carboxylase 1–dependent lipogenesis promotes autophagy downstream of AMPK. <em>Journal of Biological Chemistry</em>. https://doi.org/10.1074/jbc.ra118.007020

Vancouver

Gross AS, Zimmermann A, Pendl T, Schroeder S, Schoenlechner H, Knittelfelder O, et al. Acetyl-CoA carboxylase 1–dependent lipogenesis promotes autophagy downstream of AMPK. Journal of Biological Chemistry. 2019. doi:10.1074/jbc.ra118.007020.

BibTeX

@article{angelina2019Acetyl, title = {Acetyl-CoA carboxylase 1–dependent lipogenesis promotes autophagy downstream of AMPK}, author = {Angelina S. Gross and Andreas Zimmermann and Tobias Pendl and Sabrina Schroeder and Hannes Schoenlechner and Oskar Knittelfelder and Laura Lamplmayr and Ana Santiso and Andreas Aufschnaiter and Daniel Waltenstorfer and Sandra Ortonobes Lara and Sarah Stryeck and Christina Kast and Christoph Ruckenstuhl and Sebastian J. Hofer and Birgit Michelitsch and Martina Woelflingseder and Rolf Müller and Didac Carmona‐Gutiérrez and Tobias Madl and Sabrina Büttner and Kai‐Uwe Fröhlich and Andrej Shevchenko and Tobias Eisenberg}, journal = {Journal of Biological Chemistry}, year = {2019}, doi = {10.1074/jbc.ra118.007020}, }