Longevity intervention
Telomerase activation
- Works
- 608
- Most cited
- 2,612
Most-cited works
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
Liver cancer has the second highest worldwide cancer mortality rate and has limited therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome sequencing and DNA copy number analyses, and we analyzed 196 HCC ca...
Arterial Stiffness and Risk of Coronary Heart Disease and Stroke
BACKGROUND: Arterial stiffness has been associated with the risk of cardiovascular disease in selected groups of patients. We evaluated whether arterial stiffness is a predictor of coronary heart disease and stroke in a population-based stu...
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In particular, mutations of the telomere binding prot...
Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health
The human gut microbiome is a critical component of digestion, breaking down complex carbohydrates, proteins, and to a lesser extent fats that reach the lower gastrointestinal tract. This process results in a multitude of microbial metaboli...
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
BACKGROUND: Idiopathic pulmonary fibrosis is progressive and often fatal; causes of familial clustering of the disease are unknown. Germ-line mutations in the genes hTERT and hTR, encoding telomerase reverse transcriptase and telomerase RNA...
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers
BACKGROUND: Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) are rare and frequently lethal tumors that so far have not been subjected to comprehensive genetic characterization. METHODS: We performed next-gene...
Comparison of Allogeneic vs Autologous Bone Marrow–Derived Mesenchymal Stem Cells Delivered by Transendocardial Injection in Patients With Ischemic Cardiomyopathy
CONTEXT: Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic cardiomyopathy (ICM). Both autologous and allogeneic MSC therapies are possible; however, their safety and efficacy have not been compared. OBJECTIVE: To...
Building roots in a changing environment: implications for root longevity
Root turnover is important to the global carbon budget as well as to nutrient cycling in ecosystems and to the success of individual plants. Our ability to predict the effects of environmental change on root turnover is limited by the diffi...
Prevention of non-communicable disease in a population in nutrition transition: Tehran Lipid and Glucose Study phase II
BACKGROUND: The Tehran Lipid and Glucose Study (TLGS) is a long term integrated community-based program for prevention of non-communicable disorders (NCD) by development of a healthy lifestyle and reduction of NCD risk factors. The study be...
Inflammatory Markers and Onset of Cardiovascular Events
BACKGROUND: Inflammation plays an important role in cardiovascular disease. The aim of this study is to investigate the predictive value of several inflammatory markers on the incidence of cardiovascular events in well-functioning older per...
Frequency of TERT promoter mutations in human cancers
This 2013 Nature Communications study reports on the prevalence and distribution of TERT promoter mutations across a range of human cancer types.
Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders
Recently, clinical trials of several neurodegenerative diseases have increasingly targeted the evaluation of the effectiveness of various antioxidants. The results so far are encouraging but variable and thus confusing. Rationale for the po...