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The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Jean‐Philippe Coppé, Pierre‐Yves Desprez, Ana Krtolica, Judith Campisi

Annual Review of Pathology Mechanisms of Disease · 2010 · ▲ 5,041 citations

Cellular senescence Chronic inflammation Cell culture / in vitro

Abstract

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that turns senescent fibroblasts into proinflammatory cells that have the ability to promote tumor progression.

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Provenance

Source: OpenAlex
DOI: 10.1146/annurev-pathol-121808-102144
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Fetched: 2026-05-31 MST

Cite this

APA

Coppé, J., Desprez, P., Krtolica, A., & Campisi, J. (2010). The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression. <em>Annual Review of Pathology Mechanisms of Disease</em>. https://doi.org/10.1146/annurev-pathol-121808-102144

Vancouver

Coppé J, Desprez P, Krtolica A, Campisi J. The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression. Annual Review of Pathology Mechanisms of Disease. 2010. doi:10.1146/annurev-pathol-121808-102144.

BibTeX

@unpublished{jeanphilippe2010TheSen, title = {The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression}, author = {Jean‐Philippe Coppé and Pierre‐Yves Desprez and Ana Krtolica and Judith Campisi}, journal = {Annual Review of Pathology Mechanisms of Disease}, year = {2010}, doi = {10.1146/annurev-pathol-121808-102144}, }