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Evidence brief · hallmark

Stem-cell exhaustion

Synthesized from 10 indexed sources · 2026-07-27 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
  2. [2] A Novel Coronavirus from Patients with Pneumonia in China, 2019
  3. [3] Free radicals in biology and medicine
  4. [4] UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
  5. [5] STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION.
  6. [6] The Ensembl Variant Effect Predictor
  7. [7] DNA methylation age of human tissues and cell types
  8. [8] Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
  9. [9] Structures of naked mole-rat, tuco-tuco, and guinea pig ribosomes—is rRNA fragmentation linked to translational fidelity?
  10. [10] Embryonic stem cell-derived extracellular vesicles alleviate ovarian dysfunction.
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