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Evidence brief · hallmark

Stem-cell exhaustion

Synthesized from 10 indexed sources · 2026-06-03 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
  2. [2] Free radicals in biology and medicine
  3. [3] UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
  4. [4] STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION.
  5. [5] The Ensembl Variant Effect Predictor
  6. [6] DNA methylation age of human tissues and cell types
  7. [7] Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
  8. [8] Complement Factor H Polymorphism in Age-Related Macular Degeneration
  9. [9] Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions.
  10. [10] Cellular Senescence in Skeletal Muscle Aging.
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