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Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation

M. A. Ávila-Gálvez, Juan Antonio Giménez‐Bastida, Antonio González‐Sarrías, Juan Carlos Espı́n

Food & Function · 2019 · ▲ 59 citations

Dysbiosis Chronic inflammation

Abstract

Urolithin A (Uro-A) is an anti-inflammatory and cancer chemopreventive metabolite produced by the gut microbiota from the polyphenol ellagic acid. However, in vivo conjugation of Uro-A to Uro-A glucuronide (Uro-A glur) dramatically hampers its activity. We describe here for the first time the tissue deconjugation of Uro-A glur to Uro-A after lipopolysaccharide (LPS)-induced inflammation, which could explain the systemic in vivo activity of free Uro-A in microenvironments subjected to inflammatory stimuli.

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Provenance

Source: OpenAlex
DOI: 10.1039/c9fo00298g
Canonical: link ↗
Fetched: 2026-06-24 MST

Cite this

APA

Ávila-Gálvez, M.A., Giménez‐Bastida, J.A., González‐Sarrías, A., & Espı́n, J.C. (2019). Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation. <em>Food & Function</em>. https://doi.org/10.1039/c9fo00298g

Vancouver

Ávila-Gálvez MA, Giménez‐Bastida JA, González‐Sarrías A, Espı́n JC. Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation. Food & Function. 2019. doi:10.1039/c9fo00298g.

BibTeX

@article{m2019Tissue, title = {Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation}, author = {M. A. Ávila-Gálvez and Juan Antonio Giménez‐Bastida and Antonio González‐Sarrías and Juan Carlos Espı́n}, journal = {Food & Function}, year = {2019}, doi = {10.1039/c9fo00298g}, }