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The Telomeric Complex and Metabolic Disease

Henriette Kirchner, Fozia Shaheen, Hannes Kalscheuer, Sebastian Schmid, Henrik Oster, Hendrik Lehnert

Genes · 2017 · ▲ 44 citations

Telomere attrition Deregulated nutrient-sensing Review

Abstract

The attrition of telomeres is believed to be a key event not only in mammalian aging, but also in disturbed nutrient sensing, which could lead to numerous metabolic dysfunctions. The current debate focuses mainly on the question whether telomere shortening, e.g., as a heritable trait, may act as a cause or rather represents a consequence of such chronic diseases. This review discusses the damaging events that ultimately may lead or contribute to telomere shortening and can be associated with metabolic diseases.

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Provenance

Source: OpenAlex
DOI: 10.3390/genes8070176
Canonical: link ↗
Fetched: 2026-06-02 MST

Cite this

APA

Kirchner, H., Shaheen, F., Kalscheuer, H., Schmid, S., Oster, H., & Lehnert, H. (2017). The Telomeric Complex and Metabolic Disease. <em>Genes</em>. https://doi.org/10.3390/genes8070176

Vancouver

Kirchner H, Shaheen F, Kalscheuer H, Schmid S, Oster H, Lehnert H. The Telomeric Complex and Metabolic Disease. Genes. 2017. doi:10.3390/genes8070176.

BibTeX

@article{henriette2017TheTel, title = {The Telomeric Complex and Metabolic Disease}, author = {Henriette Kirchner and Fozia Shaheen and Hannes Kalscheuer and Sebastian Schmid and Henrik Oster and Hendrik Lehnert}, journal = {Genes}, year = {2017}, doi = {10.3390/genes8070176}, }