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The rice bran peptide KF-8 extends the lifespan and improves the healthspan of Caenorhabditis elegans via skn-1 and daf-16

Jie Cai, Zhongxu Chen, Yixin Wu, Yajuan Chen, Jianqiang Wang, Qinlu Lin, Ying Liang

Food & Function · 2022 · ▲ 24 citations

Deregulated nutrient-sensing C. elegans

Abstract

. We found that KF-8 prolonged the life of nematodes and showed no reproductive toxicity towards nematodes. In addition, KF-8 improved the motility of nematodes and resulted in an extended body length. Using hydrogen peroxide and juglone as stress inducers, we found that KF-8 improved the anti-stress ability of nematodes. In addition, KF-8 upregulated the expressions of skn-1, daf-16 and antioxidant genes. In addition, the life-prolonging effect of KF-8 was lost in skn-1 mutant strains and daf-16 mutant strains, indicating that KF-8 may exert anti-aging effects through skn-1 and daf-16.

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Provenance

Source: OpenAlex
DOI: 10.1039/d1fo03718h
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Fetched: 2026-09-02 MST

Cite this

APA

Cai, J., Chen, Z., Wu, Y., Chen, Y., Wang, J., Lin, Q., & Liang, Y. (2022). The rice bran peptide KF-8 extends the lifespan and improves the healthspan of Caenorhabditis elegans via skn-1 and daf-16. <em>Food & Function</em>. https://doi.org/10.1039/d1fo03718h

Vancouver

Cai J, Chen Z, Wu Y, Chen Y, Wang J, Lin Q, et al. The rice bran peptide KF-8 extends the lifespan and improves the healthspan of Caenorhabditis elegans via skn-1 and daf-16. Food & Function. 2022. doi:10.1039/d1fo03718h.

BibTeX

@article{jie2022Theric, title = {The rice bran peptide KF-8 extends the lifespan and improves the healthspan of Caenorhabditis elegans via skn-1 and daf-16}, author = {Jie Cai and Zhongxu Chen and Yixin Wu and Yajuan Chen and Jianqiang Wang and Qinlu Lin and Ying Liang}, journal = {Food & Function}, year = {2022}, doi = {10.1039/d1fo03718h}, }