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The Integrative Human Microbiome Project

Lita M. Proctor, Heather Huot Creasy, Jennifer M. Fettweis, Jason Lloyd‐Price, Anup Mahurkar, Wenyu Zhou, Gregory A. Buck, Michael Snyder, Jerome F. Strauss, George M. Weinstock, Owen R. White, Curtis Huttenhower

Nature · 2019 · ▲ 1,461 citations

Dysbiosis Chronic inflammation Human

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Abstract

The NIH Human Microbiome Project (HMP) has been carried out over ten years and two phases to provide resources, methods, and discoveries that link interactions between humans and their microbiomes to health-related outcomes. The recently completed second phase, the Integrative Human Microbiome Project, comprised studies of dynamic changes in the microbiome and host under three conditions: pregnancy and preterm birth; inflammatory bowel diseases; and stressors that affect individuals with prediabetes. The associated research begins to elucidate mechanisms of host-microbiome interactions under these conditions, provides unique data resources (at the HMP Data Coordination Center), and represents a paradigm for future multi-omic studies of the human microbiome.

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Provenance

Source: OpenAlex
DOI: 10.1038/s41586-019-1238-8
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Fetched: 2026-10-02 MST

Cite this

APA

Proctor, L.M., Creasy, H.H., Fettweis, J.M., Lloyd‐Price, J., Mahurkar, A., Zhou, W., Buck, G.A., Snyder, M., Strauss, J.F., Weinstock, G.M., White, O.R., & Huttenhower, C. (2019). The Integrative Human Microbiome Project. <em>Nature</em>. https://doi.org/10.1038/s41586-019-1238-8

Vancouver

Proctor LM, Creasy HH, Fettweis JM, Lloyd‐Price J, Mahurkar A, Zhou W, et al. The Integrative Human Microbiome Project. Nature. 2019. doi:10.1038/s41586-019-1238-8.

BibTeX

@article{lita2019TheInt, title = {The Integrative Human Microbiome Project}, author = {Lita M. Proctor and Heather Huot Creasy and Jennifer M. Fettweis and Jason Lloyd‐Price and Anup Mahurkar and Wenyu Zhou and Gregory A. Buck and Michael Snyder and Jerome F. Strauss and George M. Weinstock and Owen R. White and Curtis Huttenhower}, journal = {Nature}, year = {2019}, doi = {10.1038/s41586-019-1238-8}, }