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The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

Philosophical Transactions of the Royal Society B Biological Sciences · 2010 · ▲ 375 citations

Deregulated nutrient-sensing C. elegans

Abstract

Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm Caenorhabditis elegans. This discovery is described here.

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Provenance

Source: OpenAlex
DOI: 10.1098/rstb.2010.0276
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Fetched: 2026-10-22 MST

Cite this

APA

Kenyon, C.J. (2010). The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing. <em>Philosophical Transactions of the Royal Society B Biological Sciences</em>. https://doi.org/10.1098/rstb.2010.0276

Vancouver

Kenyon CJ. The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing. Philosophical Transactions of the Royal Society B Biological Sciences. 2010. doi:10.1098/rstb.2010.0276.

BibTeX

@article{cynthia2010Thefir, title = {The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing}, author = {Cynthia J. Kenyon}, journal = {Philosophical Transactions of the Royal Society B Biological Sciences}, year = {2010}, doi = {10.1098/rstb.2010.0276}, }