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The Extended Lifespan of <i>Caenorhabditis elegans rsks-1</i> Mutants Depends on the Peroxisomal Fatty Acid β-Oxidation Enzyme ACOX-1.2.

Zhao Q, Zhu R, Guo HX, Li ZX, Gong XQ, Duan JH, Ma YC, Zou CG, Wu N.

Current issues in molecular biology · 2026

Mitochondrial dysfunction Disabled macroautophagy C. elegans
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Abstract

The peroxisome has been implicated in the processes of aging and longevity regulation. Nevertheless, the mechanism by which peroxisomes regulate longevity remains far from fully elucidated. Here, we compared reactive oxygen species (ROS) levels among five long-lived <i>Caenorhabditis elegans</i> mutants using cross-validation with four different ROS probes and observed an increase in hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) levels in <i>rsks-1(ok1255)</i> mutants. Transcriptomic analysis revealed that the genes involved in peroxisomal fatty acid β-oxidation were upregulated in the <i>rsks-1(ok1255)</i> mutants. The imbalance of H<sub>2</sub>O<sub>2</sub> metabolism in the <i>rsks-1(ok1255)</i> mutants was found to be regulated by the peroxisomal fatty acid β-oxidation enzyme ACOX-1.2. Furthermore, lifespan assays and genetic analysis of transgenic strains demonstrated that the increases in autophagy(definition) and lifespan observed in long-lived <i>rsks-1(ok1255)</i> mutants were suppressed by <i>acox-1.2</i> RNAi. These findings uncover a previously unknown role of peroxisomal fatty acid β-oxidation in the regulation of aging and longevity.

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Provenance

Source
Europe PMC
DOI
10.3390/cimb48090909
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2026-10-11 MST

Cite this

APA
Q, Z., R, Z., HX, G., ZX, L., XQ, G., JH, D., YC, M., CG, Z., &amp; N., W. (2026). The Extended Lifespan of &lt;i&gt;Caenorhabditis elegans rsks-1&lt;/i&gt; Mutants Depends on the Peroxisomal Fatty Acid β-Oxidation Enzyme ACOX-1.2. <em>Current issues in molecular biology</em>. https://doi.org/10.3390/cimb48090909
Vancouver
Q Z, R Z, HX G, ZX L, XQ G, JH D, et al. The Extended Lifespan of &lt;i&gt;Caenorhabditis elegans rsks-1&lt;/i&gt; Mutants Depends on the Peroxisomal Fatty Acid β-Oxidation Enzyme ACOX-1.2. Current issues in molecular biology. 2026. doi:10.3390/cimb48090909.
BibTeX
@article{zhao2026TheExt, title = {The Extended Lifespan of &lt;i&gt;Caenorhabditis elegans rsks-1&lt;/i&gt; Mutants Depends on the Peroxisomal Fatty Acid β-Oxidation Enzyme ACOX-1.2.}, author = {Zhao Q and Zhu R and Guo HX and Li ZX and Gong XQ and Duan JH and Ma YC and Zou CG and Wu N.}, journal = {Current issues in molecular biology}, year = {2026}, doi = {10.3390/cimb48090909}, }

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