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The DNA methylation landscape of naturally short-lived killifish

Mara Steiger, Nishita Singh, Alexandra M. Tyers, Helene Kretzmer, Dario Riccardo Valenzano, Alexander Meissner

Scientific Reports · 2026 · ▲ 1 citations

Abstract

Annual killifish of the genus Nothobranchius are naturally short-lived vertebrates that exhibit a wide range of aging characteristics typically observed in mammals. Here, we provide the first comprehensive whole-genome methylation map for two species, revealing local age-related as well as tissue-specific dynamics in the DNA methylome. Our maps and results support the annual killifish as a model organism and further highlight its value for studying aging including possible health status predictions in vertebrates.

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Provenance

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OpenAlex
DOI
10.1038/s41598-026-39352-3
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2026-07-07 MST

Cite this

APA
Steiger, M., Singh, N., Tyers, A.M., Kretzmer, H., Valenzano, D.R., &amp; Meissner, A. (2026). The DNA methylation landscape of naturally short-lived killifish. <em>Scientific Reports</em>. https://doi.org/10.1038/s41598-026-39352-3
Vancouver
Steiger M, Singh N, Tyers AM, Kretzmer H, Valenzano DR, Meissner A. The DNA methylation landscape of naturally short-lived killifish. Scientific Reports. 2026. doi:10.1038/s41598-026-39352-3.
BibTeX
@article{mara2026TheDNA, title = {The DNA methylation landscape of naturally short-lived killifish}, author = {Mara Steiger and Nishita Singh and Alexandra M. Tyers and Helene Kretzmer and Dario Riccardo Valenzano and Alexander Meissner}, journal = {Scientific Reports}, year = {2026}, doi = {10.1038/s41598-026-39352-3}, }

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