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The DNA methylation landscape of naturally short-lived killifish.

Steiger M, Singh N, Tyers AM, Kretzmer H, Valenzano DR, Meissner A.

Scientific reports · 2026 · ▲ 1 citations

Epigenetic alterations Killifish

Abstract

Annual killifish of the genus Nothobranchius are naturally short-lived vertebrates that exhibit a wide range of aging characteristics typically observed in mammals. Here, we provide the first comprehensive whole-genome methylation map for two species, revealing local age-related as well as tissue-specific dynamics in the DNA methylome. Our maps and results support the annual killifish as a model organism and further highlight its value for studying aging including possible health status predictions in vertebrates.

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Provenance

Source: Europe PMC
DOI: 10.1038/s41598-026-39352-3
Canonical: link ↗
Fetched: 2026-07-01 MST

Cite this

APA

M, S., N, S., AM, T., H, K., DR, V., & A., M. (2026). The DNA methylation landscape of naturally short-lived killifish. <em>Scientific reports</em>. https://doi.org/10.1038/s41598-026-39352-3

Vancouver

M S, N S, AM T, H K, DR V, A. M. The DNA methylation landscape of naturally short-lived killifish. Scientific reports. 2026. doi:10.1038/s41598-026-39352-3.

BibTeX

@article{steiger2026TheDNA, title = {The DNA methylation landscape of naturally short-lived killifish.}, author = {Steiger M and Singh N and Tyers AM and Kretzmer H and Valenzano DR and Meissner A.}, journal = {Scientific reports}, year = {2026}, doi = {10.1038/s41598-026-39352-3}, }