The Association between Diet Quality and Inflammatory Biomarkers among College-aged Women

Inflammation status has been associated with chronic diseases such as Type 2 Diabetes, cardiovascular disease and cancer. Previous studies suggested that healthful dietary patterns and dietary scores may have been associated with reduced concentrations of inflammatory biomarkers. However, studies have been usually conducted among middle- aged and older adults by examining commonly used biomarkers such as C-Reactive Protein (CRP) and Interleukin 6 (IL-6). For the current study, diet quality was measured by applying food frequency data to create the 2010 Dietary Guidelines for Americans Adherence Index (DGAI-2010). Concentrations of inflammatory biomarkers were obtained from fasting blood samples collected at the late-luteal phase of paticipants’ menstrual cycle. We used linear regression to analyze the association between each natural log-transformed inflammatory biomarker concentration and the continuous DGAI-2010 Score among 142 young, healthy women (aged 18-30 years) from the UMass Vitamin D Status Study. We found that as diet quality increased, concentrations of IL-7, IL-12p70, IL-13 and IFN- were significantly lower after adjustment for BMI, age, physical activity, smoking, race/ethnicity, multivitamin use, oral contraceptive use, and total energy intake per day. Following a diet that adheres to the Dietary Guidelines for Americans as a measure of dietary quality is associated with lower inflammation in healthy, normal weight and overweight young women.