Temporal order deterioration and circadian disruption with age 1. Central and peripheral mechanisms

The review presents recent data on the mechanisms of temporal dynamics of aging processes. The general principle of changes in multioscillatory network of phenotypic functions in the form of extracircadian dissemination has been described: the frequency transposition of variability in ultra- and infradian ranges accompanied by the loss of phase stability of the circadian rhythm. Heterochronic molecular, genetic, morphological, and functional changes of the central oscillator and the cells of the peripheral tissues were analyzed. Age-dependent circadian disruption is considered as a result of gradual nonspecific loss of molecular, genetic, tissue, and systemic factors synchronizing the circadian rhythm.