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Telomere Shortening of Peripheral Blood Mononuclear Cells in Coronary Disease Patients with Metabolic Disorders.

Nobuya Obana, Sho Takagi, Yoshitaka Kinouchi, Yoshihisa Tokita, Akihiro Sekikawa, Seiichi Takahashi, Nobuo Hiwatashi, Shinichi Oikawa, Tooru Shimosegawa

Internal Medicine · 2003 · ▲ 63 citations

Telomere attrition Human
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Abstract

OBJECTIVE: Telomere(definition) shortening is correlated with cell turnover and aging, but it has been recently suggested to occur not only by aging but by several biochemical factors of metabolic disorders predisposing to atherosclerosis. PATIENTS AND METHODS: We compared telomere length of peripheral blood mononuclear cells of patients with the metabolic disorders, hypercholesterolemia (HC) and diabetes mellitus (DM), according to the presence or absence of coronary diseases. RESULTS: The results demonstrated that HC and/or DM patients with coronary diseases have significantly shorter telomere length than healthy controls (p = 0.0014). CONCLUSION: Telomere shortening may be involved in the mechanisms that promote coronary diseases under some circumstances of metabolic disorders.

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Provenance

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OpenAlex
DOI
10.2169/internalmedicine.42.150
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2026-06-09 MST

Cite this

APA
Obana, N., Takagi, S., Kinouchi, Y., Tokita, Y., Sekikawa, A., Takahashi, S., Hiwatashi, N., Oikawa, S., &amp; Shimosegawa, T. (2003). Telomere Shortening of Peripheral Blood Mononuclear Cells in Coronary Disease Patients with Metabolic Disorders. <em>Internal Medicine</em>. https://doi.org/10.2169/internalmedicine.42.150
Vancouver
Obana N, Takagi S, Kinouchi Y, Tokita Y, Sekikawa A, Takahashi S, et al. Telomere Shortening of Peripheral Blood Mononuclear Cells in Coronary Disease Patients with Metabolic Disorders. Internal Medicine. 2003. doi:10.2169/internalmedicine.42.150.
BibTeX
@article{nobuya2003Telome, title = {Telomere Shortening of Peripheral Blood Mononuclear Cells in Coronary Disease Patients with Metabolic Disorders.}, author = {Nobuya Obana and Sho Takagi and Yoshitaka Kinouchi and Yoshihisa Tokita and Akihiro Sekikawa and Seiichi Takahashi and Nobuo Hiwatashi and Shinichi Oikawa and Tooru Shimosegawa}, journal = {Internal Medicine}, year = {2003}, doi = {10.2169/internalmedicine.42.150}, }

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