Open access · OA via OpenAlex

Telomere Shortening of Peripheral Blood Mononuclear Cells in Coronary Disease Patients with Metabolic Disorders.

Nobuya Obana, Sho Takagi, Yoshitaka Kinouchi, Yoshihisa Tokita, Akihiro Sekikawa, Seiichi Takahashi, Nobuo Hiwatashi, Shinichi Oikawa, Tooru Shimosegawa

Internal Medicine · 2003 · ▲ 63 citations

Telomere attrition Human

＋ Sign in to save

Abstract

OBJECTIVE: Telomere shortening is correlated with cell turnover and aging, but it has been recently suggested to occur not only by aging but by several biochemical factors of metabolic disorders predisposing to atherosclerosis. PATIENTS AND METHODS: We compared telomere length of peripheral blood mononuclear cells of patients with the metabolic disorders, hypercholesterolemia (HC) and diabetes mellitus (DM), according to the presence or absence of coronary diseases. RESULTS: The results demonstrated that HC and/or DM patients with coronary diseases have significantly shorter telomere length than healthy controls (p = 0.0014). CONCLUSION: Telomere shortening may be involved in the mechanisms that promote coronary diseases under some circumstances of metabolic disorders.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.2169/internalmedicine.42.150
Canonical: link ↗
Fetched: 2026-06-09 MST

Cite this

APA

Obana, N., Takagi, S., Kinouchi, Y., Tokita, Y., Sekikawa, A., Takahashi, S., Hiwatashi, N., Oikawa, S., & Shimosegawa, T. (2003). Telomere Shortening of Peripheral Blood Mononuclear Cells in Coronary Disease Patients with Metabolic Disorders. <em>Internal Medicine</em>. https://doi.org/10.2169/internalmedicine.42.150

Vancouver

Obana N, Takagi S, Kinouchi Y, Tokita Y, Sekikawa A, Takahashi S, et al. Telomere Shortening of Peripheral Blood Mononuclear Cells in Coronary Disease Patients with Metabolic Disorders. Internal Medicine. 2003. doi:10.2169/internalmedicine.42.150.

BibTeX

@article{nobuya2003Telome, title = {Telomere Shortening of Peripheral Blood Mononuclear Cells in Coronary Disease Patients with Metabolic Disorders.}, author = {Nobuya Obana and Sho Takagi and Yoshitaka Kinouchi and Yoshihisa Tokita and Akihiro Sekikawa and Seiichi Takahashi and Nobuo Hiwatashi and Shinichi Oikawa and Tooru Shimosegawa}, journal = {Internal Medicine}, year = {2003}, doi = {10.2169/internalmedicine.42.150}, }