Telomere and Aging Why Your Chromosome Has Shoelace TipsTelomeres—the repetitive nucleoprotein caps at the ends of linear chromosomes—function as protective "aglets" that prevent genomic instability and progressive DNA loss. This review synthesizes four decades of telomere research, from the discovery of the end‑replication problem to the latest insights into shelterin dynamics, telomerase regulation, and the non‑linear shortening of telomeres across the human lifespan. We critically examine the mechanistic links between telomere attrition, cellular senescence, oxidative stress, and mitochondrial dysfunction, and evaluate the evidence that positions telomere length as both a biomarker and a potential driver of biological aging. The clinical relevance of telomere biology is illustrated through disorders such as Dyskeratosis Congenita and the dual role of telomerase in cancer. Finally, we assess emerging interventions—from lifestyle modification to telomerase activators and gene‑editing approaches—and highlight key methodological pitfalls in telomere length measurement. By integrating structural, molecular, epidemiological, and clinical perspectives, this review provides a balanced, evidence‑based framework for understanding telomeres as central players in the aging process.

Tariq, T., &amp; Sadiq, L. (2026). Telomere and Aging Why Your Chromosome Has Shoelace TipsTelomeres—the repetitive nucleoprotein caps at the ends of linear chromosomes—function as protective "aglets" that prevent genomic instability and progressive DNA loss. This review synthesizes four decades of telomere research, from the discovery of the end‑replication problem to the latest insights into shelterin dynamics, telomerase regulation, and the non‑linear shortening of telomeres across the human lifespan. We critically examine the mechanistic links between telomere attrition, cellular senescence, oxidative stress, and mitochondrial dysfunction, and evaluate the evidence that positions telomere length as both a biomarker and a potential driver of biological aging. The clinical relevance of telomere biology is illustrated through disorders such as Dyskeratosis Congenita and the dual role of telomerase in cancer. Finally, we assess emerging interventions—from lifestyle modification to telomerase activators and gene‑editing approaches—and highlight key methodological pitfalls in telomere length measurement. By integrating structural, molecular, epidemiological, and clinical perspectives, this review provides a balanced, evidence‑based framework for understanding telomeres as central players in the aging process. <em>Knowledge Commons (Lakehead University)</em>. https://doi.org/10.17613/wb2jz-5hz21

Tariq T, Sadiq L. Telomere and Aging Why Your Chromosome Has Shoelace TipsTelomeres—the repetitive nucleoprotein caps at the ends of linear chromosomes—function as protective "aglets" that prevent genomic instability and progressive DNA loss. This review synthesizes four decades of telomere research, from the discovery of the end‑replication problem to the latest insights into shelterin dynamics, telomerase regulation, and the non‑linear shortening of telomeres across the human lifespan. We critically examine the mechanistic links between telomere attrition, cellular senescence, oxidative stress, and mitochondrial dysfunction, and evaluate the evidence that positions telomere length as both a biomarker and a potential driver of biological aging. The clinical relevance of telomere biology is illustrated through disorders such as Dyskeratosis Congenita and the dual role of telomerase in cancer. Finally, we assess emerging interventions—from lifestyle modification to telomerase activators and gene‑editing approaches—and highlight key methodological pitfalls in telomere length measurement. By integrating structural, molecular, epidemiological, and clinical perspectives, this review provides a balanced, evidence‑based framework for understanding telomeres as central players in the aging process. Knowledge Commons (Lakehead University). 2026. doi:10.17613/wb2jz-5hz21.

@unpublished{tayyaba2026Telome, title = {Telomere and Aging Why Your Chromosome Has Shoelace TipsTelomeres—the repetitive nucleoprotein caps at the ends of linear chromosomes—function as protective "aglets" that prevent genomic instability and progressive DNA loss. This review synthesizes four decades of telomere research, from the discovery of the end‑replication problem to the latest insights into shelterin dynamics, telomerase regulation, and the non‑linear shortening of telomeres across the human lifespan. We critically examine the mechanistic links between telomere attrition, cellular senescence, oxidative stress, and mitochondrial dysfunction, and evaluate the evidence that positions telomere length as both a biomarker and a potential driver of biological aging. The clinical relevance of telomere biology is illustrated through disorders such as Dyskeratosis Congenita and the dual role of telomerase in cancer. Finally, we assess emerging interventions—from lifestyle modification to telomerase activators and gene‑editing approaches—and highlight key methodological pitfalls in telomere length measurement. By integrating structural, molecular, epidemiological, and clinical perspectives, this review provides a balanced, evidence‑based framework for understanding telomeres as central players in the aging process.}, author = {Tayyaba Tariq and Laraib Sadiq}, journal = {Knowledge Commons (Lakehead University)}, year = {2026}, doi = {10.17613/wb2jz-5hz21}, }