Targeting Longevity: Supplements as Interventions to Modulate Aging Pathways and Enhance Healthspan

The aging process, characterized by the progressive decline of cellular and physiological functions, can be influenced by nutritional and pharmacological interventions. Recent research highlights the potential of various supplements to slow aspects of biological aging by targeting key mechanisms such as oxidative stress, inflammation, mitochondrial dysfunction(definition), and genomic instability. Compounds like antioxidants (vitamins C and E), coenzyme Q10, omega-3 fatty acids, polyphenols (such as resveratrol), and NAD⁺ precursors have shown promise in promoting cellular health and extending healthspan(definition). Additionally, supplements that modulate nutrient-sensing pathways, such as mTOR(definition)-inhibiting drug studied for extending healthspan and lifespan." style="text-decoration:underline dotted; text-underline-offset:2px; cursor:help;">rapamycin(definition) analogs and metformin, are being explored for their anti-aging effects. While supplements offer a promising approach to support healthy aging, their efficacy and safety require further validation through long-term clinical studies. A deeper understanding of personalized supplementation strategies may pave the way for individualized interventions to enhance longevity and quality of life.