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Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment

Proceedings of the National Academy of Sciences · 2019 · ▲ 114 citations

Loss of proteostasis Mouse

Abstract

-methyl-d-aspartate (NMDA) receptors, thereby increasing synaptic connectivity. Mass spectrometry revealed that thrombospondin-4 (THBS4) and SPARC-like protein 1 (SPARCL1) were enriched in serum from young mice. Strikingly, recombinant THBS4 and SPARCL1 both increased dendritic arborization and doubled synapse numbers in cultured neurons. In addition, SPARCL1 but not THBS4 tripled NMDA receptor-mediated synaptic responses. Thus, at least two proteins enriched in young blood, THBS4 and SPARCL1, directly act on neurons as synaptogenic factors. These proteins may represent rejuvenation factors that enhance synaptic connectivity by increasing dendritic arborization, synapse formation, and synaptic transmission.

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Provenance

Source: OpenAlex
DOI: 10.1073/pnas.1902672116
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Fetched: 2026-06-23 MST

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APA

Gan, K.J., & Südhof, T.C. (2019). Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment. <em>Proceedings of the National Academy of Sciences</em>. https://doi.org/10.1073/pnas.1902672116

Vancouver

Gan KJ, Südhof TC. Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment. Proceedings of the National Academy of Sciences. 2019. doi:10.1073/pnas.1902672116.

BibTeX

@article{kathlyn2019Specif, title = {Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment}, author = {Kathlyn J. Gan and Thomas C. Südhof}, journal = {Proceedings of the National Academy of Sciences}, year = {2019}, doi = {10.1073/pnas.1902672116}, }