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SenCat: Cataloging human cell senescence through multi-omic profiling of multiple senescent primary cell types.

Anerillas C, Altés G, Gresova K, Tsitsipatis D, Mazan-Mamczarz K, Banarjee R, Cunningham ASG, Salamini-Montemurri M, Yang JH, Munk R, Rossi M, Piao Y, Olinger B, Strassheim Q, Martindale JL

Molecular cell · 2026

Cellular senescence Human Mouse

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Abstract

There is an urgent need to comprehensively catalog senescence markers across cell types in an organism in order to characterize senescent-cell heterogeneity. Here, we profiled the transcriptomes and proteomes in 14 different primary human cell types undergoing over 30 senescence paradigms to create a senescence catalog we termed "SenCat." We found that while senescent cells from all primary cell types did not share a single unique marker, they did activate shared specific metabolic and damage-response pathways implicated in tissue repair. Moreover, machine-learning-refined SenCat signatures enabled senescence scoring and identification across multiple human and mouse datasets, both at bulk and single-cell levels. In sum, SenCat represents a much-needed resource to identify senescence across multiple cell types and tissues in the body.

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Provenance

Source: Europe PMC
DOI: 10.1016/j.molcel.2026.05.017
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Fetched: 2026-07-02 MST

Cite this

APA

C, A., G, A., K, G., D, T., K, M., R, B., ASG, C., M, S., JH, Y., R, M., M, R., Y, P., B, O., Q, S., JL, M., J, F., CY, C., S, D., DV, R., & Y, H. (2026). SenCat: Cataloging human cell senescence through multi-omic profiling of multiple senescent primary cell types. <em>Molecular cell</em>. https://doi.org/10.1016/j.molcel.2026.05.017

Vancouver

C A, G A, K G, D T, K M, R B, et al. SenCat: Cataloging human cell senescence through multi-omic profiling of multiple senescent primary cell types. Molecular cell. 2026. doi:10.1016/j.molcel.2026.05.017.

BibTeX

@article{anerillas2026SenCat, title = {SenCat: Cataloging human cell senescence through multi-omic profiling of multiple senescent primary cell types.}, author = {Anerillas C and Altés G and Gresova K and Tsitsipatis D and Mazan-Mamczarz K and Banarjee R and Cunningham ASG and Salamini-Montemurri M and Yang JH and Munk R and Rossi M and Piao Y and Olinger B and Strassheim Q and Martindale JL and Fan J and Cui CY and De S and Rutherford DV and Hao Y and Li Z and Roberts J and Qi YA and Abdelmohsen K and de Cabo R}, journal = {Molecular cell}, year = {2026}, doi = {10.1016/j.molcel.2026.05.017}, }