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Safety of Mesenchymal Stem Cells for Clinical Application

Youwei Wang, Zhibo Han, Yongping Song, Zhong Chao Han

Stem Cells International · 2012 · ▲ 207 citations

Stem-cell exhaustion Stem-cell therapy Cell culture / in vitro Human In vitro
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Abstract

Mesenchymal stem cells (MSCs) hold great promise as therapeutic agents in regenerative medicine and autoimmune diseases, based on their differentiation abilities and immunosuppressive properties. However, the therapeutic applications raise a series of questions about the safety of culture-expanded MSCs for human use. This paper summarized recent findings about safety issues of MSCs, in particular their genetic stability in long-term in vitro expansion, their cryopreservation, banking, and the role of serum in the preparation of MSCs.

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Provenance

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OpenAlex
DOI
10.1155/2012/652034
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2026-06-21 MST

Cite this

APA
Wang, Y., Han, Z., Song, Y., &amp; Han, Z.C. (2012). Safety of Mesenchymal Stem Cells for Clinical Application. <em>Stem Cells International</em>. https://doi.org/10.1155/2012/652034
Vancouver
Wang Y, Han Z, Song Y, Han ZC. Safety of Mesenchymal Stem Cells for Clinical Application. Stem Cells International. 2012. doi:10.1155/2012/652034.
BibTeX
@article{youwei2012Safety, title = {Safety of Mesenchymal Stem Cells for Clinical Application}, author = {Youwei Wang and Zhibo Han and Yongping Song and Zhong Chao Han}, journal = {Stem Cells International}, year = {2012}, doi = {10.1155/2012/652034}, }

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