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Mesenchymal Stem/Stromal Cells: A New ''Cells as Drugs'' Paradigm. Efficacy and Critical Aspects in Cell Therapy

Laura de Girolamo, Enrico Lucarelli, Giulio Alessandri, Maria Antonietta Avanzini, Maria Ester Bernardo, Ettore Biagi, A.T. Brini, Giovanna D’Amico, Franca Fagioli, Ivana Ferrero, Franco Locatelli, Rita Maccario, Mario Marazzi, Ornella Parolini, Augusto Pessina

Current Pharmaceutical Design · 2013 · ▲ 159 citations

Stem-cell exhaustion Stem-cell therapy Human Review
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Abstract

Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of action is undefined and currently under investigation. For in vivo purposes MSCs must be produced in compliance with good manufacturing practices and this has stimulated research on MSCs characterization and safety. The objective of this review is to describe recent developments regarding MSCs properties, physiological effects, delivery, clinical applications and possible side effects. Keywords: Mesenchymal stem/stromal cells, cell therapy, graft versus host disease, immunomodulatory properties, regenerative medicine, advanced therapy medicinal product, transplantation, MSCs sources, clinical trials, clinical applications

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Provenance

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OpenAlex
DOI
10.2174/1381612811319130015
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2026-06-11 MST

Cite this

APA
Girolamo, L.D., Lucarelli, E., Alessandri, G., Avanzini, M.A., Bernardo, M.E., Biagi, E., Brini, A., D’Amico, G., Fagioli, F., Ferrero, I., Locatelli, F., Maccario, R., Marazzi, M., Parolini, O., Pessina, A., &amp; Group, M.I.M.S.C. (2013). Mesenchymal Stem/Stromal Cells: A New &amp;apos;&amp;apos;Cells as Drugs&amp;apos;&amp;apos; Paradigm. Efficacy and Critical Aspects in Cell Therapy. <em>Current Pharmaceutical Design</em>. https://doi.org/10.2174/1381612811319130015
Vancouver
Girolamo LD, Lucarelli E, Alessandri G, Avanzini MA, Bernardo ME, Biagi E, et al. Mesenchymal Stem/Stromal Cells: A New &amp;apos;&amp;apos;Cells as Drugs&amp;apos;&amp;apos; Paradigm. Efficacy and Critical Aspects in Cell Therapy. Current Pharmaceutical Design. 2013. doi:10.2174/1381612811319130015.
BibTeX
@article{laura2013Mesenc, title = {Mesenchymal Stem/Stromal Cells: A New &amp;apos;&amp;apos;Cells as Drugs&amp;apos;&amp;apos; Paradigm. Efficacy and Critical Aspects in Cell Therapy}, author = {Laura de Girolamo and Enrico Lucarelli and Giulio Alessandri and Maria Antonietta Avanzini and Maria Ester Bernardo and Ettore Biagi and A.T. Brini and Giovanna D’Amico and Franca Fagioli and Ivana Ferrero and Franco Locatelli and Rita Maccario and Mario Marazzi and Ornella Parolini and Augusto Pessina and Maria Italian Mesenchymal Stem Cell Group}, journal = {Current Pharmaceutical Design}, year = {2013}, doi = {10.2174/1381612811319130015}, }

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